Molecular structure of Diminazene Aceturate, CAS Number: 908-54-3
Diminazene Aceturate (CAS 908-54-3)
See product citations (11)
Alternate Names:
Diminazene Aceturate is known as an anti-protozoal diamidine.
Application:
Diminazene Aceturate is an anti-protozoal and anti-trypanosomal diamidine that affects a variety of enzymes.
CAS Number:
908-54-3
Purity:
≥97%
Molecular Weight:
515.52
Molecular Formula:
C22H29N9O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diminazene Aceturate is a diamidine with anti-protozoal and anti-trypanosomal properties. Diminazene Aceturate is an activator of ACE2. Similar to other diamidines, Diminazene Aceturate affects a variety of enzymes and can modulate the interactions between nucleic acids and proteins. In rat tests, Diminazene Aceturate has shown the ability to enhance enzymatic activity of angiotensin-converting enzyme 2.
Diminazene Aceturate (CAS 908-54-3) References
- The pharmacokinetics of diminazene aceturate after intramuscular administration in healthy dogs. | Miller, DM., et al. 2005. J S Afr Vet Assoc. 76: 146-50. PMID: 16300182
- Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs. | Akpa, PO., et al. 2008. Vet Parasitol. 151: 139-49. PMID: 18155842
- Current advances in detection and treatment of babesiosis. | Mosqueda, J., et al. 2012. Curr Med Chem. 19: 1504-18. PMID: 22360483
- Biochemical and morphological changes in Trypanosoma brucei brucei-infected rats treated with homidium chloride and diminazene aceturate. | Adeyemi, OS. and Sulaiman, FA. 2012. J Basic Clin Physiol Pharmacol. 23: 179-83. PMID: 23072845
- Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models. | Shenoy, V., et al. 2013. Am J Respir Crit Care Med. 187: 648-57. PMID: 23370913
- Some non-conventional biomolecular targets for diamidines. A short survey. | Huang, TL., et al. 2014. Bioorg Med Chem. 22: 1983-92. PMID: 24630693
- Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice. | Qiu, Y., et al. 2014. Invest Ophthalmol Vis Sci. 55: 3809-18. PMID: 24854854
- Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei. | Munday, JC., et al. 2015. Front Pharmacol. 6: 32. PMID: 25814953
- Anti-hypertensive Effects of Diminazene Aceturate: An Angiotensin- Converting Enzyme 2 Activator in Rats. | De Maria, ML., et al. 2016. Protein Pept Lett. 23: 9-16. PMID: 26458404
- Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics. | da Silva Oliveira, GL. and de Freitas, RM. 2015. Pharmacol Res. 102: 138-57. PMID: 26470648
- Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-κB pathways in human retinal pigment epithelium. | Tao, L., et al. 2016. J Neuroinflammation. 13: 35. PMID: 26862037
- Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes. | Goru, SK., et al. 2017. Br J Pharmacol. 174: 3118-3130. PMID: 28688122
- The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice. | Rajapaksha, IG., et al. 2018. Sci Rep. 8: 10175. PMID: 29977014
Inhibitor of:
AdoMetDC, ATR, PAOX, SPDSY, SSAT2, and VibH.Activator of:
ACE, APLNR, and ODCp.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diminazene Aceturate, 1 g | sc-205651 | 1 g | $90.00 | |||
Diminazene Aceturate, 5 g | sc-205651A | 5 g | $370.00 |