Molecular structure of Digoxin-d3, CAS Number: 127299-95-0
Digoxin-d3 (CAS 127299-95-0)
Alternate Names:
(3β,5β,12β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxyl]-12,14-dihydroxycard-20(22)-enolide-d3; Digacin-d3; Dilanacin-d3; Lanicor-d3
Application:
Digoxin-d3 is a deuterium-labeled digoxin compound
CAS Number:
127299-95-0
Purity:
≥97%
Molecular Weight:
783.96
Molecular Formula:
C41H61D3O14
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Labelled Diogoxin. A representative lot is 95.4% d3, 3.4% d2, 1.2% d1 no dectable d0.
Digoxin-d3 (CAS 127299-95-0) References
- Therapeutic monitoring of serum digoxin for patients with heart failure using a rapid LC-MS/MS method. | Li, S., et al. 2010. Clin Biochem. 43: 307-13. PMID: 19833118
- Effect of telaprevir on the pharmacokinetics of midazolam and digoxin. | Garg, V., et al. 2012. J Clin Pharmacol. 52: 1566-73. PMID: 22162542
- Effects of multiple doses of albiglutide on the pharmacokinetics, pharmacodynamics, and safety of digoxin, warfarin, or a low-dose oral contraceptive. | Bush, M., et al. 2012. Postgrad Med. 124: 55-72. PMID: 23322139
- Pharmacokinetic and pharmacodynamic drug-drug interaction assessment between pradigastat and digoxin or warfarin. | Yan, JH., et al. 2014. J Clin Pharmacol. 54: 800-8. PMID: 24619917
- Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies. | Martin, P., et al. 2015. Clin Ther. 37: 2811-22. PMID: 26514315
- Effects of Rolapitant Administered Intravenously or Orally on the Pharmacokinetics of Digoxin (P-glycoprotein Substrate) and Sulfasalazine (Breast Cancer Resistance Protein Substrate) in Healthy Volunteers. | Wang, X., et al. 2018. J Clin Pharmacol. 58: 202-211. PMID: 28906558
- Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects. | Kirigaya, Y., et al. 2020. BMC Pharmacol Toxicol. 21: 55. PMID: 32727577
- Development of a new ultra-high-performance liquid chromatography-tandem mass spectrometry method for the determination of digoxin and digitoxin in plasma: Comparison with a clinical immunoassay. | Ballotari, M., et al. 2022. Electrophoresis. 43: 1019-1026. PMID: 35132652
- A cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis. | Carroll, E., et al. 2023. Nat Commun. 14: 4042. PMID: 37422531
- Clinical pharmacokinetics of digoxin 1980. | Aronson, JK. 1980. Clin Pharmacokinet. 5: 137-49. PMID: 6988136
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Digoxin-d3, 2.5 mg | sc-218220 | 2.5 mg | $418.00 | |||
Digoxin-d3, 10 mg | sc-218220A | 10 mg | $1193.00 | |||
Digoxin-d3, 25 mg | sc-218220B | 25 mg | $2448.00 |