Date published: 2026-5-22

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DICA (CAS 613665-26-2)

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Alternate Names:
2-(2,4-Dichlorophenoxy)-N-(2-mercaptoethyl)acetamide
Application:
DICA is an inhibitor of caspase-3 and caspase-7
CAS Number:
613665-26-2
Purity:
98%
Molecular Weight:
280.2
Molecular Formula:
C10H11Cl2NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DICA, or 3,4-dichloroaniline, is a chemical compound characterized by its aniline structure substituted with two chlorine atoms at the 3 and 4 positions on the benzene ring. This configuration imparts notable chemical properties, including increased reactivity and stability, making it a useful intermediate in various chemical synthesis processes. DICA is particularly utilized in the manufacture of dyes, pigments, and where its ability to participate in coupling reactions is essential. The dichloro substitution enhances its electrophilic properties, making it more reactive in nucleophilic substitution reactions, which are pivotal in building complex aromatic compounds. DICA may serve as a building block in the synthesis of agrochemicals and other specialty chemicals, where its structural components contribute to the efficacy and stability of the final products. The specific electronic effects of the chlorine atoms also influence the electronic distribution across the molecule, affecting its interaction with other chemical entities.


DICA (CAS 613665-26-2) References

  1. Discovery of an allosteric site in the caspases.  |  Hardy, JA., et al. 2004. Proc Natl Acad Sci U S A. 101: 12461-6. PMID: 15314233
  2. Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species.  |  Du, JQ., et al. 2008. J Biol Chem. 283: 30205-15. PMID: 18768468
  3. Allosteric modulation of caspases.  |  Häcker, HG., et al. 2011. Pharmacol Ther. 132: 180-95. PMID: 21807025
  4. Caspase-3 Inhibition Prediction of Pyrrolo [3, 4-c] Quinoline-1, 3-Diones Derivatives using Computational Tools  |  Pandey, V. 2021. Indian Journal of Pharmaceutical Sciences. 83(3): 504-514.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DICA, 5 mg

sc-202135
5 mg
$63.00

DICA, 25 mg

sc-202135A
25 mg
$300.00