Date published: 2025-11-14

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Dibutyl phosphate (CAS 107-66-4)

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Alternate Names:
Di-n-butylphosphoric acid
CAS Number:
107-66-4
Molecular Weight:
210.21
Molecular Formula:
C8H19O4P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dibutyl phosphate, an organophosphate ester, finds extensive applications in scientific research, particularly in biochemical and physiological experiments. With its solubility in polar organic solvents like ethanol, methanol, and dimethyl sulfoxide (DMSO), as well as its miscibility with water in any proportion, it offers versatility in various experimental setups. Its primary use lies in serving as a reagent for the synthesis of diverse organophosphates such as phospholipids and phosphonates. Furthermore, dibutyl phosphate plays a role in synthesizing phosphorylated compounds, which are vital for studying enzyme inhibition. It also contributes significantly to the synthesis of phosphorylated peptides and proteins, enabling in-depth investigations into enzyme kinetics.


Dibutyl phosphate (CAS 107-66-4) References

  1. Direct determination of dibutyl and monobutyl phosphate in a tributyl phosphate/nitric aqueous-phase system by electrospray mass spectrometry.  |  Lamouroux, C., et al. 2000. Anal Chem. 72: 1186-91. PMID: 10740858
  2. Direct determination of phosphate esters in concentrated nitrate media by capillary zone electrophoresis.  |  Rivasseau, C., et al. 2003. J Chromatogr A. 1015: 219-31. PMID: 14570333
  3. Determination of dialkyl phosphate metabolites of organophosphorus pesticides in human urine by automated solid-phase extraction, derivatization, and gas chromatography-mass spectrometry.  |  Hemakanthi De Alwis, GK., et al. 2008. J Anal Toxicol. 32: 721-7. PMID: 19021926
  4. 1H NMR-based metabonomic investigation of tributyl phosphate exposure in rats.  |  Neerathilingam, M., et al. 2010. Toxicol Lett. 199: 10-6. PMID: 20688139
  5. Dissolution of synthetic uranium dibutyl phosphate deposits in oxidizing and reducing chemical formulations.  |  Rufus, AL., et al. 2013. J Hazard Mater. 254-255: 263-269. PMID: 23624355
  6. Biodegradation of tributyl phosphate using Klebsiella pneumoniae sp. S3.  |  Kulkarni, SV., et al. 2014. Appl Microbiol Biotechnol. 98: 919-29. PMID: 23644771
  7. Tributyl phosphate biodegradation to butanol and phosphate and utilization by a novel bacterial isolate, Sphingobium sp. strain RSMS.  |  Rangu, SS., et al. 2014. Appl Microbiol Biotechnol. 98: 2289-96. PMID: 23963271
  8. Biodegradation of tributyl phosphate, an organosphate triester, by aerobic granular biofilms.  |  Nancharaiah, YV., et al. 2015. J Hazard Mater. 283: 705-11. PMID: 25464313
  9. Involvement of phosphoesterases in tributyl phosphate degradation in Sphingobium sp. strain RSMS.  |  Rangu, SS., et al. 2016. Appl Microbiol Biotechnol. 100: 461-8. PMID: 26399413
  10. Thermally Induced Protonation of Conducting Polyaniline Film by Dibutyl Phosphite Conversion to Phosphate.  |  Trchová, M., et al. 2018. J Phys Chem A. 122: 9492-9497. PMID: 30462508
  11. Short-term variability in levels of urinary phosphate flame retardant metabolites in adults and children from an e-waste recycling site.  |  Shi, Y., et al. 2019. Chemosphere. 234: 395-401. PMID: 31228842
  12. Sustainable Bio-Based UV-Cured Epoxy Vitrimer from Castor Oil.  |  Bergoglio, M., et al. 2023. Polymers (Basel). 15: PMID: 36850307
  13. Organophosphate polyneuropathy in chicks.  |  Peraica, M., et al. 1993. Biochem Pharmacol. 45: 131-5. PMID: 8381002
  14. Intracellular sorting of lysosomal beta-glucuronidase is altered due to administration of dibutyl phosphate.  |  Nishimura, Y., et al. 1995. J Biochem. 118: 46-55. PMID: 8537325

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dibutyl phosphate, 250 ml

sc-257325
250 ml
$51.00