Date published: 2026-5-20

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Deoxypyridinoline (CAS 83462-55-9)

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Application:
Deoxypyridinoline is called D-Pyrilinks, Pyrilinks-D, or deoxyPYD, is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones.
CAS Number:
83462-55-9
Molecular Weight:
412.44
Molecular Formula:
C18H28N4O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Deoxypyridinoline (DPD) is a specialized biochemical compound, it is a pyridinium type crosslink, for the stabilization of collagen fibers, primarily in bone and dentin. Its presence is almost exclusive to bone and dentin, differentiating it from other pyridinium crosslinks. Deoxypyridinoline is pivotal in understanding the processes of bone degradation and remodeling. When bone tissue undergoes resorption, Deoxypyridinoline is released, which researchers can then measure in biological samples. Furthermore, studying Deoxypyridinoline contributes to a deeper comprehension of collagen crosslinking and its impact on the mechanical properties of bone. This research is essential in fields like biochemistry and molecular biology, where understanding the fundamental aspects of bone structure and function is critical.


Deoxypyridinoline (CAS 83462-55-9) References

  1. Deoxypyridinoline crosslinks in human dentin and estimation of age.  |  Martin-de las Heras, S., et al. 1999. Int J Legal Med. 112: 222-6. PMID: 10433031
  2. Dietary sodium, an independent determinant for urinary deoxypyridinoline in elderly women. A cross-sectional study on the effect of dietary factors on deoxypyridinoline excretion in 24-h urine specimens from 763 free-living healthy Japanese.  |  Itoh, R., et al. 1999. Eur J Clin Nutr. 53: 886-90. PMID: 10557002
  3. Urinary deoxypyridinoline excretion for the evaluation of bone turnover in chronic renal failure.  |  Coen, G., et al. 2000. Am J Nephrol. 20: 283-90. PMID: 10970981
  4. Assessment and recommendations on factors contributing to preanalytical variability of urinary pyridinoline and deoxypyridinoline.  |  Vesper, HW., et al. 2002. Clin Chem. 48: 220-35. PMID: 11805003
  5. Osteocalcin, deoxypyridinoline and interleukin-1beta in peri-implant crevicular fluid of patients with peri-implantitis.  |  Murata, M., et al. 2002. Clin Oral Implants Res. 13: 637-43. PMID: 12519339
  6. Utility of urinary pyridinoline and deoxypyridinoline ratio for diagnosis of osteoarthritis at temporomandibular joint.  |  Tanimoto, K., et al. 2004. J Oral Pathol Med. 33: 218-23. PMID: 15061709
  7. Is deoxypyridinoline a good resorption marker to detect osteopenia in phenylketonuria?  |  Millet, P., et al. 2005. Clin Biochem. 38: 1127-32. PMID: 16256974
  8. Urinary bone resorption markers (deoxypyridinoline and C-terminal telopeptide of type I collagen) in healthy persons, postmenopausal osteoporosis and patients with type I diabetes.  |  Fassbender, WJ., et al. 2009. Adv Med Sci. 54: 1-6. PMID: 19482729
  9. Screening for salivary levels of deoxypyridinoline and bone-specific alkaline phosphatase during orthodontic tooth movement: a pilot study.  |  Flórez-Moreno, GA., et al. 2013. Eur J Orthod. 35: 361-8. PMID: 22247225
  10. Diagnostic performance of the urinary deoxypyridinoline in spinal tuberculosis.  |  Shi, J., et al. 2012. Orthopedics. 35: e922-6. PMID: 22691668
  11. Activity restriction increases deoxypyridinoline excretion in hospitalized high-risk pregnant women.  |  Vanderspank, D., et al. 2014. Biol Res Nurs. 16: 7-15. PMID: 23079370
  12. Urinary levels of pyridinoline and deoxypyridinoline and bone mineral density in children with type 1 diabetes mellitus.  |  Sav, NM., et al. 2017. Endocr Res. 42: 281-286. PMID: 28318333
  13. Rapid analysis of pyridinoline and deoxypyridinoline in biological samples by liquid chromatography with mass spectrometry and a silica hydride column.  |  Naffa, R., et al. 2019. J Sep Sci. 42: 1482-1488. PMID: 30680922

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Deoxypyridinoline, 5 mg

sc-499927
5 mg
$1020.00