Molecular structure of Demeclocycline, CAS Number: 127-33-3
Demeclocycline (CAS 127-33-3)
Alternate Names:
6-Demethylchlortetracycline
Application:
Demeclocycline is a broad specrum antibacterial and an antiprotozoan chlortetracycline analogue
CAS Number:
127-33-3
Molecular Weight:
464.85
Molecular Formula:
C21H21ClN2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Demeclocycline (Declomycin), a semi-synthetic derivative of tetracycline which makes it useful as a reference compound in analytical chemistry. In research laboratories to develop and validate analytical methods for detecting tetracyclines in biological and environmental samples. As a compound with fluorescent properties, demeclocycline can be applied in fluorescence microscopy and other imaging techniques that investigate the presence and concentration of tetracycline-like substances. In the field of biochemistry, it is utilized to study the binding affinity of tetracycline compounds to various proteins and biomolecules.
Demeclocycline (CAS 127-33-3) References
- Improvements in europium sensitized fluorimetric determination of demeclocycline and methacycline. | Mahedero, MC., et al. 2005. J Pharm Biomed Anal. 37: 1101-4. PMID: 15862691
- Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. | Jiang, SX., et al. 2005. J Biol Chem. 280: 33811-8. PMID: 16091365
- Preparation and characterization of demeclocycline liposomal formulations and assessment of their intraocular pressure-lowering effects. | Afouna, MI., et al. 2005. Cutan Ocul Toxicol. 24: 111-24. PMID: 17040889
- Preparation of aqueous two-phase systems composed of two pH-response polymers and liquid-liquid extraction of demeclocycline. | Yan, B. and Cao, X. 2012. J Chromatogr A. 1245: 39-45. PMID: 22658298
- Development and validation of a reversed-phase liquid chromatographic method for analysis of demeclocycline and related impurities. | Kahsay, G., et al. 2012. J Sep Sci. 35: 1310-8. PMID: 22733511
- Comparative evaluation of methylene blue and demeclocycline for enhancing optical contrast of gliomas in optical images. | Wirth, D., et al. 2014. J Biomed Opt. 19: 90504. PMID: 25239672
- Demeclocycline as a contrast agent for detecting brain neoplasms using confocal microscopy. | Wirth, D., et al. 2015. Phys Med Biol. 60: 3003-11. PMID: 25790138
- Tetracyclines function as dual-action light-activated antibiotics. | He, Y., et al. 2018. PLoS One. 13: e0196485. PMID: 29742128
- Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes. | Sarkar, S., et al. 2020. Front Immunol. 11: 272. PMID: 32153581
- Metabolic engineering of a methyltransferase for production of drug precursors demecycline and demeclocycline in Streptomyces aureofaciens. | Yang, W., et al. 2020. Synth Syst Biotechnol. 5: 121-130. PMID: 32637665
- Electrooxidation of tetracycline antibiotic demeclocycline at unmodified boron-doped diamond electrode and its enhancement determination in surfactant-containing media. | Allahverdiyeva, S., et al. 2021. Talanta. 223: 121695. PMID: 33303147
- Tetracyclines Enhance Anti-tumor T-Cell Responses Induced by a Bispecific T-Cell Engager. | Noguchi, Y., et al. 2022. Biol Pharm Bull. 45: 429-437. PMID: 35370267
- Evaluation of the diffusion of triamcinolone and demeclocycline through the dentinal tubules and apical foramen: A mass spectrometry study. | Wong, M., et al. 2022. J Conserv Dent. 25: 420-425. PMID: 36187869
- Selective Antibody-Free Sensing Membranes for Picogram Tetracycline Detection. | Ben Halima, H., et al. 2022. Biosensors (Basel). 13: PMID: 36671906
- Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives. | Tourville, A., et al. 2023. Antioxidants (Basel). 12: PMID: 36978822
Inhibitor of:
UT-A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Demeclocycline, 5 mg | sc-391514 | 5 mg | $121.00 |