Date published: 2025-10-20

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δ-Valerolactone (CAS 542-28-9)

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Alternate Names:
Tetrahydro-2H-pyran-2-one
CAS Number:
542-28-9
Molecular Weight:
100.12
Molecular Formula:
C5H8O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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δ-Valerolactone is a water-soluble sodium salt that exhibits a low melting point and high vapor pressure. It has been used as a sample preparation agent in NMR spectroscopy and as an ingredient in the formulation of cosmetics. Notably, this compound may act to have antimicrobial activity against Escherichia coli K-12. While δ-Valerolactone does not significantly impact the activity of enzymes such as acetylcholinesterase, butylcholinesterase, or aminopyrine N-demethylase, it serves as a valuable component in the synthesis of copolyesters via lipase-catalyzed ring opening polymerization.


δ-Valerolactone (CAS 542-28-9) References

  1. Why delta-valerolactone polymerizes and gamma-butyrolactone does not.  |  Houk, KN., et al. 2008. J Org Chem. 73: 2674-8. PMID: 18324833
  2. Experimental and computational studies on the mechanism of zwitterionic ring-opening polymerization of δ-valerolactone with N-heterocyclic carbenes.  |  Acharya, AK., et al. 2014. J Phys Chem B. 118: 6553-60. PMID: 24702523
  3. Impregnation of poly(L-lactide-ran-δ-valerolactone) with essential bark oil using supercritical carbon dioxide.  |  Tsutsumi, C., et al. 2019. Sci Rep. 9: 16326. PMID: 31705062
  4. Towards Advances in Molecular Understanding of Boric Acid Biocatalyzed Ring-Opening (Co)Polymerization of δ-Valerolactone in the Presence of Ethylene Glycol as an Initiator.  |  Duale, K., et al. 2021. Molecules. 26: PMID: 34443448
  5. Binary catalytic system for homo- and block copolymerization of ε-caprolactone with δ-valerolactone.  |  Wang, Y., et al. 2020. RSC Adv. 10: 25979-25987. PMID: 35518598
  6. Understanding the hydrolysis mechanism on segments and aggregate structures: Corrosion-tailored poly (lactic acid) deriving copolymers with δ-valerolactone.  |  Huang, W., et al. 2022. Int J Biol Macromol. 222: 961-971. PMID: 36181885
  7. Room-Temperature Ring-Opening Polymerization of δ-Valerolactone and ϵ-Caprolactone Caused by Uptake into Porous Pillar[5]arene Crystals.  |  Kato, K., et al. 2022. Angew Chem Int Ed Engl. 61: e202212874. PMID: 36203324
  8. A photoswitchable organocatalyst controls trimethylene carbonate and δ-valerolactone copolymerization.  |  Riffel, MN., et al. 2018. Sci Bull (Beijing). 63: 1460-1461. PMID: 36658825
  9. Oligomerization of ɛ-caprolactone and δ-valerolactone using heteropolyacid initiators and vanadium or molybdenum complexes  |  Mahha, Y., Atlamsani, A., Blais, J. C., Tessier, M., Brégeault, J. M., & Salles, L. 2005. Journal of Molecular Catalysis A: Chemical. 234(1-2): 63-73.
  10. Development of poly (ε-caprolactone-co-l-lactide) and poly (ε-caprolactone-co-δ-valerolactone) as new degradable binder used for antifouling paint  |  Faÿ, F., Renard, E., Langlois, V., Linossier, I., & Vallée-Rehel, K. 2007. European polymer journal. 43(11): 4800-4813.
  11. Imidodiphosphoric acid as a bifunctional catalyst for the controlled ring-opening polymerization of δ-valerolactone and ε-caprolactone  |  Kan, S., Jin, Y., He, X., Chen, J., Wu, H., Ouyang, P.,.. & Li, Z. 2013. Polymer Chemistry. 4(21): 5432-5439.
  12. Highly Active Yttrium Catalysts for the Ring-Opening Polymerization of ε-Caprolactone and δ-Valerolactone  |  Xinke Wang, Jonathan L. Brosmer, Arnaud Thevenon, and Paula L. Diaconescu*. 2015. Organometallics. 34(19): 4700–4706.
  13. Organoaluminium Complexes Derived from Anilines or Schiff Bases for the Ring-Opening Polymerization of ε-Caprolactone, δ-Valerolactone and rac-Lactide  |  Wang, X., Zhao, K. Q., Al‐Khafaji, Y., Mo, S., Prior, T. J., Elsegood, M. R., & Redshaw, C. 2017. European Journal of Inorganic Chemistry. 2017(13): 1951-1965.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

δ-Valerolactone, 25 ml

sc-251415
25 ml
$36.00