DBH Antibody (8.F.304): sc-58518

DBH Antibody (8.F.304) is a mouse monoclonal IgG1 antibody that detects dopamine beta-hydroxylase (DBH) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). DBH plays a crucial role in the biosynthesis of catecholamines by catalyzing the conversion of dopamine to noradrenaline, which is essential for various physiological processes, including the regulation of mood, attention, and the body′s response to stress. DBH is predominantly expressed in noradrenergic and adrenergic neurons, as well as in neuroendocrine cells, making DBH a specific marker for noradrenergic activity. The active form of DBH is a homotetramer located in the lumen of synaptic vesicles, where DBH associates with both the membrane and cytosol, highlighting DBH′s importance in neurotransmitter storage and release. Additionally, DBH expression is influenced by nerve growth factor and insulin growth factor-1, and DBH is regulated by intracellular signaling pathways involving protein kinase A, cyclic AMP, diacylglycerol, and calcium ions. Transcriptional regulation of DBH is mediated by key proteins such as Sp1, CREB, and AP-1 family members, including c-Fos, c-Jun, and JunD, underscoring the complexity of DBH expression control. Anti-DBH antibody (8.F.304) is an invaluable tool for researchers studying noradrenergic signaling and its implications in neurobiology and related disorders.

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DBH Antibody (8.F.304) References:

1. Dopamine beta-hydroxylase (DBH) activity and -1021C/T polymorphism of DBH gene in combat-related post-traumatic stress disorder.  |  Mustapić, M., et al. 2007. Am J Med Genet B Neuropsychiatr Genet. 144B: 1087-9. PMID: 17853400
2. HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma.  |  Huang, JL., et al. 2015. Oncotarget. 6: 33791-804. PMID: 26393879
3. Downregulation of long non-coding RNA DBH-AS1 inhibits osteosarcoma progression by PI3K-AKT signaling pathways and indicates good prognosis.  |  Liu, ZB., et al. 2019. Eur Rev Med Pharmacol Sci. 23: 1418-1427. PMID: 30840262
4. Dopamine β hydroxylase as a potential drug target to combat hypertension.  |  Dey, SK., et al. 2020. Expert Opin Investig Drugs. 29: 1043-1057. PMID: 32658551
5. Heterotrimeric PCNA increases the activity and fidelity of Dbh, a Y-family translesion DNA polymerase prone to creating single-base deletion mutations.  |  Wu, Y., et al. 2020. DNA Repair (Amst). 96: 102967. PMID: 32961405
6. Increased m6A modification of lncRNA DBH-AS1 suppresses pancreatic cancer growth and gemcitabine resistance via the miR-3163/USP44 axis.  |  Ye, X., et al. 2022. Ann Transl Med. 10: 304. PMID: 35433957
7. Duret Brainstem Hemorrhage After Transtentorial Descending Brain Herniation: A Systematic Review and Meta-Analysis.  |  Beucler, N., et al. 2023. World Neurosurg. 173: 251-262.e4. PMID: 36868404
8. Dynamics and thermal stability of the bypass polymerase, DinB homolog (Dbh).  |  Soto, J., et al. 2024. Front Mol Biosci. 11: 1364068. PMID: 38745908
9. Dopamine-beta-hydroxylase (DBH) and homovanillic acid (HVA) in autistic children.  |  Garnier, C., et al. 1986. J Autism Dev Disord. 16: 23-9. PMID: 3957856
10. Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings.  |  Wrenn, CC., et al. 1996. Brain Res. 740: 175-84. PMID: 8973812

The preferred DBH antibody is DBH Antibody (A-9): sc-365710.