Date published: 2026-4-27

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DAR-1 (CAS 261351-43-3)

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Alternate Names:
4,5-Diamino-rhodamine B; 4,5-Diamino-N,N,N′,N′-tetraethylrhodamine
Application:
DAR-1 is a sensitive fluorescent indicator for nitric oxide
CAS Number:
261351-43-3
Purity:
≥97%
Molecular Weight:
472.58
Molecular Formula:
C28H32N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DAR-1 is a highly fluorescent, water-soluble dye extensively employed in various scientific research applications. This molecular characteristic serves as a foundation for its utilization in various scientific research applications. In the realm of cell biology, DAR-1 aids in exploring the intricate structure and functionality of cells. In the field of biochemistry, it enables investigations into the structure and behavior of proteins and enzymes. The fluorescent properties of DAR-1 stem from its ability to emit light upon excitation by a specific wavelength. This emission is a direct consequence of the dye′s structural composition. With a conjugated system comprising alternating single and double bonds, the dye effectively absorbs light of a particular wavelength and emits light at a longer wavelength, contributing to its observable fluorescence.


DAR-1 (CAS 261351-43-3) References

  1. Cloning, sequencing, expression and allelic sequence diversity of ERG3 (C-5 sterol desaturase gene) in Candida albicans.  |  Miyazaki, Y., et al. 1999. Gene. 236: 43-51. PMID: 10433965
  2. Type A allatostatins from Drosophila melanogaster and Diplotera puncata activate two Drosophila allatostatin receptors, DAR-1 and DAR-2, expressed in CHO cells.  |  Larsen, MJ., et al. 2001. Biochem Biophys Res Commun. 286: 895-901. PMID: 11527383
  3. Identification of four Drosophila allatostatins as the cognate ligands for the Drosophila orphan receptor DAR-2.  |  Lenz, C., et al. 2001. Biochem Biophys Res Commun. 286: 1117-22. PMID: 11527415
  4. Molecular cloning of a functional allatostatin gut/brain receptor and an allatostatin preprohormone from the silkworm Bombyx mori.  |  Secher, T., et al. 2001. J Biol Chem. 276: 47052-60. PMID: 11590150
  5. Immunocytochemical analysis of putative allatostatin receptor (DAR-2) distribution in the CNS of larval Drosophila melanogaster.  |  Bowser, PR. and Tobe, SS. 2005. Peptides. 26: 81-7. PMID: 15626507
  6. Molecular cloning and characterization of an allatostatin-like receptor in the cockroach Diploptera punctata.  |  Lungchukiet, P., et al. 2008. Peptides. 29: 276-85. PMID: 18237821
  7. Defining the contribution of select neuropeptides and their receptors in regulating sesquiterpenoid biosynthesis by Drosophila melanogaster ring gland/corpus allatum through RNAi analysis.  |  Wang, C., et al. 2012. Gen Comp Endocrinol. 176: 347-53. PMID: 22245290
  8. The FGLamide-allatostatins influence foraging behavior in Drosophila melanogaster.  |  Wang, C., et al. 2012. PLoS One. 7: e36059. PMID: 22558326
  9. A fluorogenic assay for methylglyoxal.  |  Shaheen, F., et al. 2014. Biochem Soc Trans. 42: 548-55. PMID: 24646277
  10. Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates.  |  Sukumaran, S., et al. 2015. Pharm Res. 32: 1884-93. PMID: 25446772
  11. Effects of diacerein on the quantity and phagocytic activity of thioglycollate-elicited mouse peritoneal macrophages.  |  Mian, M., et al. 1989. Pharmacology. 39: 362-6. PMID: 2634854
  12. Applications of SNAP-tag technology in skin cancer therapy.  |  Padayachee, ER., et al. 2019. Health Sci Rep. 2: e103. PMID: 30809593
  13. Mitochondrial dysfunction, autophagy stimulation and non-apoptotic cell death caused by nitric oxide-inducing Pt-coated Au nanoparticle in human lung carcinoma cells.  |  Akhtar, MJ., et al. 2020. Biochim Biophys Acta Gen Subj. 1864: 129452. PMID: 31676295

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DAR-1, 1 mg

sc-214855
1 mg
$198.00