Date published: 2026-5-28

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DAPH (CAS 145915-58-8)

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Application:
DAPH is an inhibitor of EGFR kinase 3
CAS Number:
145915-58-8
Molecular Weight:
329.4
Molecular Formula:
C20H15N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DAPH is frequently used in the field of analytical chemistry as a chromogenic reagent due to its ability to form colored complexes with various metal ions. This property makes DAPH a useful tool in spectrophotometric assays for the detection and quantification of metal ions in solution. In environmental research, DAPH can be employed to monitor the presence of trace metals in water samples, contributing to the assessment of water quality and pollution. In coordination chemistry, DAPH serves as a ligand to synthesize novel metal complexes, allowing researchers to study their structural and electronic properties. These complexes are of interest for their potential catalytic activities and for understanding metal-ligand interactions at a fundamental level. Additionally, DAPH-derived complexes are explored for their photophysical properties, which could be harnessed in the development of optical materials, sensors, or molecular electronics.


DAPH (CAS 145915-58-8) References

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  2. Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination.  |  Hennessy, EJ. and Buchwald, SL. 2005. J Org Chem. 70: 7371-5. PMID: 16122261
  3. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.  |  Wang, H., et al. 2008. Proc Natl Acad Sci U S A. 105: 7159-64. PMID: 18480256
  4. Thioflavin T fluorescence assay for beta-lactoglobulin fibrils hindered by DAPH.  |  Kroes-Nijboer, A., et al. 2009. J Struct Biol. 165: 140-5. PMID: 19063973
  5. Novel anilinophthalimide derivatives as potential probes for beta-amyloid plaque in the brain.  |  Duan, XH., et al. 2010. Bioorg Med Chem. 18: 1337-43. PMID: 20036557
  6. Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.  |  Takahashi, K., et al. 2010. Biochem Biophys Res Commun. 402: 54-8. PMID: 20888320
  7. 4,5-dianilinophtalimide protects neuroendocrine cells against serum deprivation-induced stress and apoptosis.  |  Ergin, V., et al. 2013. Neuro Endocrinol Lett. 34: 359-65. PMID: 23922036
  8. Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity.  |  Takahashi, I., et al. 1989. Biochem Biophys Res Commun. 165: 1207-12. PMID: 2558652
  9. Preparation of 4-(4'-Hydroxyanilino)-5-anilinophthalimide and 4,5-Bis-(4'-hydroxyanilino)-phthalimide by Microbial Hydroxylation.  |  Weidner, S., et al. 1999. Biosci Biotechnol Biochem. 63: 1497-500. PMID: 27389513
  10. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.  |  Meruelo, D., et al. 1988. Proc Natl Acad Sci U S A. 85: 5230-4. PMID: 2839837
  11. 4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.  |  Buchdunger, E., et al. 1994. Proc Natl Acad Sci U S A. 91: 2334-8. PMID: 8134396
  12. Retinoic acid-induced RB (retinoblastoma) hypophosphorylation enhanced by CGP 52411 (4,5-dianilinophthalimide), an EGF family tyrosine kinase receptor inhibitor.  |  Yen, A. and Soong, S. 1996. Eur J Cell Biol. 69: 327-34. PMID: 8741214
  13. Therapy of human transitional cell carcinoma of the bladder by oral administration of the epidermal growth factor receptor protein tyrosine kinase inhibitor 4,5-dianilinophthalimide.  |  Dinney, CP., et al. 1997. Clin Cancer Res. 3: 161-8. PMID: 9815668

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DAPH, 5 mg

sc-200698
5 mg
$130.00