D3DR Antibody (9F4): sc-136170

D3DR Antibody (9F4) is a mouse monoclonal IgM antibody that detects D3DR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-D3DR antibody (9F4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. D3DR protein, a member of the dopamine receptor family, plays a crucial role in the central nervous system by mediating dopamine effects, a key neurotransmitter involved in regulating mood, cognition, and motor control. D3DR is primarily located in the limbic areas of the brain, which are associated with emotional responses and reward pathways. This localization suggests D3DR may be involved in modulating behaviors related to motivation and pleasure, making D3DR a potential target for therapeutic interventions in conditions such as schizophrenia and drug addiction. D3DR interaction with other proteins, such as G-proteins, further underscores D3DR importance in signal transduction pathways that influence neuronal activity and synaptic plasticity.

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D3DR Antibody (9F4) References:

1. No association between the serotonin transporter promoter region (5-HTTLPR) and the dopamine D3 receptor (BalI D3DR) polymorphisms and heroin addiction.  |  Kotler, M., et al. 1999. Mol Psychiatry. 4: 313-4. PMID: 10483044
2. The splice variant D3nf reduces ligand binding to the D3 dopamine receptor: evidence for heterooligomerization.  |  Elmhurst, JL., et al. 2000. Brain Res Mol Brain Res. 80: 63-74. PMID: 11039730
3. Structural subtypes of the dopamine D2 receptor are functionally distinct: expression of the cloned D2A and D2B subtypes in a heterologous cell line.  |  Hayes, G., et al. 1992. Mol Endocrinol. 6: 920-6. PMID: 1323056
4. Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor.  |  Hausdorff, WP., et al. 1990. Symp Soc Exp Biol. 44: 225-40. PMID: 1983369
5. Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.  |  Cotecchia, S., et al. 1990. J Biol Chem. 265: 63-9. PMID: 2152928
6. Cross-sectional and longitudinal small animal PET shows pre and post-synaptic striatal dopaminergic deficits in an animal model of HIV.  |  Sinharay, S., et al. 2017. Nucl Med Biol. 55: 27-33. PMID: 29031113
7. Exploring the structural basis and atomistic binding mechanistic of the selective antagonist blockade at D3 dopamine receptor over D2 dopamine receptor.  |  Appiah-Kubi, P., et al. 2021. J Mol Recognit. 34: e2885. PMID: 33401335
8. Agonist-induced desensitization of dopamine D1 receptor-stimulated adenylyl cyclase activity is temporally and biochemically separated from D1 receptor internalization.  |  Ng, GY., et al. 1995. Proc Natl Acad Sci U S A. 92: 10157-61. PMID: 7479745
9. The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor.  |  Barak, LS., et al. 1995. Biochemistry. 34: 15407-14. PMID: 7492540
10. Molecular and chemical neuropharmacology of dopamine receptor subtypes.  |  Ogawa, N. 1995. Acta Med Okayama. 49: 1-11. PMID: 7762403
11. The D2 dopamine receptor isoforms signal through distinct Gi alpha proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi alpha proteins.  |  Senogles, SE. 1994. J Biol Chem. 269: 23120-7. PMID: 7916015
12. 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms.  |  Ebstein, RP., et al. 1997. Am J Med Genet. 74: 65-72. PMID: 9034010

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-D3DR Antibody (9F4) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-D3DR Antibody (9F4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

D3DR Antibody (9F4) Specifications

Alternate Product Name: D3DR

Product Clone Name: 9F4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 210-218

Epitope Target: D3DR

Epitope Species: human

Product Reactivity/Detection: D3DR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for D3DR Antibody (9F4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin