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D-myo-Inositol-1,4,5-trisphosphate hexapotassium salt (CAS 103476-24-0)

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Alternate Names:
Ins(1,4,5)P3 . 6K; IP3
Application:
D-myo-Inositol-1,4,5-trisphosphate hexapotassium salt is a second messenger produced in cells that signals the release of Ca2+
CAS Number:
103476-24-0
Purity:
≥98%
Molecular Weight:
648.6
Molecular Formula:
C6H9O15P36K
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-myo-Inositol-1,4,5-triphosphate hexapotassium salt, referred to as IP3, is a pivotal compound in cellular biology research due to its role as a second messenger within biological systems. It is central to studies on intracellular signal transduction pathways, where it mediates the release of calcium from intracellular stores into the cytosol following activation by various extracellular signals. This compound is integral in examining the mechanisms of signal amplification and the intricate network of intracellular signaling cascades. Researchers utilize D-myo-Inositol-1,4,5-triphosphate hexapotassium salt to investigate cellular responses to hormones, growth factors, and neurotransmitters. Furthermore, its involvement in various physiological processes, such as muscle contraction, neuronal activity, and secretion, makes it an essential molecule for studies on cellular function and communication. The hexapotassium salt form of IP3 is favored in experimental applications due to its improved solubility and stability, allowing for its use in a range of in vitro assays.


D-myo-Inositol-1,4,5-trisphosphate hexapotassium salt (CAS 103476-24-0) References

  1. Inositol 1,4,5-trisphosphate-activated calcium channels.  |  Ferris, CD. and Snyder, SH. 1992. Annu Rev Physiol. 54: 469-88. PMID: 1314042
  2. Reduction of infarct size with D-myo-inositol trisphosphate: role of PI3-kinase and mitochondrial K(ATP) channels.  |  Przyklenk, K., et al. 2006. Am J Physiol Heart Circ Physiol. 290: H830-6. PMID: 16183728
  3. Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway.  |  Sang, N., et al. 2010. Neurochem Int. 56: 590-6. PMID: 20064571
  4. A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.  |  Costa, RR., et al. 2010. Am J Physiol Cell Physiol. 299: C316-23. PMID: 20519450
  5. Inositol-1,4,5-trisphosphate induced Ca2+ release and excitation-contraction coupling in atrial myocytes from normal and failing hearts.  |  Hohendanner, F., et al. 2015. J Physiol. 593: 1459-77. PMID: 25416623
  6. Molecular recognition of inositol polyphosphates by intracellular receptors and metabolic enzymes.  |  Nahorski, SR. and Potter, BV. 1989. Trends Pharmacol Sci. 10: 139-44. PMID: 2546303
  7. Inositol phosphates and cell signalling.  |  Berridge, MJ. and Irvine, RF. 1989. Nature. 341: 197-205. PMID: 2550825
  8. The metabolism of phosphoinositide-derived messenger molecules.  |  Majerus, PW., et al. 1986. Science. 234: 1519-26. PMID: 3024320
  9. Inositol trisphosphate and diacylglycerol: two interacting second messengers.  |  Berridge, MJ. 1987. Annu Rev Biochem. 56: 159-93. PMID: 3304132
  10. Relationship between secretagogue-induced Ca2+ release and inositol polyphosphate production in permeabilized pancreatic acinar cells.  |  Streb, H., et al. 1985. J Biol Chem. 260: 7309-15. PMID: 3997871
  11. myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.  |  Joseph, SK., et al. 1984. J Biol Chem. 259: 3077-81. PMID: 6607924
  12. Inositol 1,4,5-trisphosphate and calcium regulate the calcium channel function of the hepatic inositol 1,4,5-trisphosphate receptor.  |  Dufour, JF., et al. 1997. J Biol Chem. 272: 2675-81. PMID: 9006903

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-myo-Inositol-1,4,5-trisphosphate hexapotassium salt, 1 mg

sc-201521
1 mg
$302.00