D-myo-Inositol-1,4,5,6-tetraphosphate, sodium salt CAS: 157542-47-7
MF: C6H12O18P4•4Na
MW: 588.0
An inositol implicated in signal transduction.

D-myo-Inositol-1,4,5,6-tetraphosphate, sodium salt (CAS 157542-47-7)

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Alternate Names: Ins(1,4,5,6)-P4; 1,4,5,6-IP4
Application: D-myo-Inositol-1,4,5,6-tetraphosphate, sodium salt is an inositol implicated in signal transduction
CAS Number: 157542-47-7
Molecular Weight: 588.0
Molecular Formula: C6H12O18P44Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

D-myo-Inositol-1,4,5,6-tetraphosphate, sodium salt is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)P4 by intestinal epithelial cells increases approximately 2-14 fold, following infection with Salmonella. Ins(1,4,5,6)P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins(1,4,5,6)P3 is less potent than Ins(1,4,5)P3 at initiating Ca2+ release when injected into Xenopus oocytes.


References

1 Eckmann, L., Rudolf, M.T., Ptasznik, A., et al. D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways. Proc Natl Acad Sci USA 94 14456-14460 (1997). 2 DeLisle, S., Radenberg, T., Wintermantel, M.R., et al. Second messenger specificity of the inositol trisphosphate receptor: Reappraisal based on novel inositol phosphates. Am J Physiol Cell Physiol 35 C429-C436 (1994).

Appearance :
Lyophilized powder
Physical State :
Solid
Solubility :
Soluble in water (≥50 mg/ml). Practically insoluble in organic solvents.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
[Na+].[Na+].[Na+].[Na+].O[[email protected]]1[[email protected]@H](OP(=O)([O-])O)[[email protected]](OP(=O)([O-])O)[[email protected]@H](OP(=O)([O-])O)[[email protected]](OP(=O)([O-])O)[[email protected]]1O

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Certificate of Analysis

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