Date published: 2025-12-1

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D-(−)-Pantolactone (CAS 599-04-2)

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Alternate Names:
(R)-(−)-Pantolactone Pantoic acid γ-lactone (R)-(−)-β,β-Dimethyl-α-hydroxy-γ-butyrolactone (R)-(−)-α-Hydroxy-β,β-dimethyl-γ-butyrolactone (R)-(−)-4,5-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone D-(−)-alpha-Hydroxy-beta,beta-dimethyl-gamma-butyrolactone
CAS Number:
599-04-2
Molecular Weight:
130.14
Molecular Formula:
C6H10O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-(−)-Pantolactone is a cyclic beta-hydroxy acid that possesses a lactone structure. It acts as a reagent in various biochemical and physiological investigations. D-(−)-Pantolactone also acts as a precursor for the synthesis of organic compounds, including polymers and other materials. Although the precise mechanism of action of D-(−)-Pantolactone remains elusive, it is believed to function as an inhibitor of the enzyme cyclooxygenase (COX).


D-(−)-Pantolactone (CAS 599-04-2) References

  1. Synthesis of molluscicidal agent cyanolide a macrolactone from D-(-)-pantolactone.  |  Hajare, AK., et al. 2011. J Org Chem. 76: 963-6. PMID: 21192736
  2. Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase.  |  Awuah, E., et al. 2014. Bioorg Med Chem. 22: 3083-90. PMID: 24814884
  3. Elucidation of key aroma compounds in traditional dry fermented sausages using different extraction techniques.  |  Corral, S., et al. 2015. J Sci Food Agric. 95: 1350-61. PMID: 25043208
  4. Fine Tuning of Pyrene Excimer Fluorescence in Molecular Beacons by Alteration of the Monomer Structure.  |  Aparin, IO., et al. 2017. J Org Chem. 82: 10015-10024. PMID: 28856889
  5. Identification and Biochemical Characterization of a Novel Hormone-Sensitive Lipase Family Esterase Est19 from the Antarctic Bacterium Pseudomonas sp. E2-15.  |  Liu, X., et al. 2021. Biomolecules. 11: PMID: 34827549
  6. Biocatalysis of heterogenously-expressed d-lactonohydrolases and its efficient preparation of desirable d-pantoic acid.  |  Sun, R., et al. 2022. Enzyme Microb Technol. 155: 109981. PMID: 35007923
  7. Biocatalytic kinetic resolution of d,l-pantolactone by using a novel recombinant d-lactonase.  |  Zhang, QH., et al. 2020. RSC Adv. 11: 721-725. PMID: 35423680
  8. Industrial kinetic resolution of d,l-pantolactone by an immobilized whole-cell biocatalyst.  |  Zhang, QH., et al. 2021. RSC Adv. 11: 30373-30376. PMID: 35480294
  9. Whether the Research on Ethanol-Water Microstructure in Traditional Baijiu Should Be Strengthened?  |  Qin, D., et al. 2022. Molecules. 27: PMID: 36500382
  10. Optimization and Preparation of Tallow with a Strong Aroma by Mild Oxidation.  |  Jin, Y., et al. 2022. Molecules. 27: PMID: 36558180
  11. Tuning an efficient Escherichia coli whole-cell catalyst expressing l-pantolactone dehydrogenase for the biosynthesis of d-(-)-pantolactone.  |  Zhu, FY., et al. 2023. J Biotechnol. 367: 1-10. PMID: 36948403
  12. Recent Developments in the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors Incorporating Pyridine Moiety.  |  Starosotnikov, AM. and Bastrakov, MA. 2023. Int J Mol Sci. 24: PMID: 37298265
  13. Increasing catalytic efficiency of SceCPR by semi-rational engineering towards the asymmetric reduction of D-pantolactone.  |  Zhao, M., et al. 2023. J Biotechnol. 373: 34-41. PMID: 37392996

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-(−)-Pantolactone, 5 g

sc-357326
5 g
$42.00

D-(−)-Pantolactone, 25 g

sc-357326A
25 g
$106.00