Date published: 2025-12-3

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D-Glucose-6,6-d2 (CAS 18991-62-3)

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Alternate Names:
D-[6,6′-2H2]Glucose
Application:
D-Glucose-6,6-d2 is a labeled glucose compound
CAS Number:
18991-62-3
Purity:
98%
Molecular Weight:
182.17
Molecular Formula:
C6D2H10O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-Glucose-6,6-d2 is a stable isotope-labeled form of glucose where both hydrogens at the 6th carbon position are replaced with deuterium. This compound is particularly useful in metabolic research, where it is employed to trace and analyze metabolic pathways involving glucose. By incorporating D-Glucose-6,6-d2 into experimental protocols, researchers can monitor its conversion into other metabolites using techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, which can differentiate between deuterated and non-deuterated species. This allows for detailed studies of glucose utilization, glycogen synthesis, and the pentose phosphate pathway. Additionally, D-Glucose-6,6-d2 is used in research to understand glucose transport mechanisms and the regulation of blood sugar levels in cells and tissues. The use of stable isotope tracers like D-Glucose-6,6-d2 is a critical aspect of metabolic research that provides insights into the dynamics of glucose metabolism under various physiological and experimental conditions.


D-Glucose-6,6-d2 (CAS 18991-62-3) References

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  2. Counterregulatory responses to hypoglycemia differ between glimepiride and glyburide in non diabetic individuals.  |  Joy, NG., et al. 2015. Metabolism. 64: 729-37. PMID: 25765720
  3. Responses of plasma glucose metabolism to exogenous insulin infusion in sheep-fed forage herb plantain and exposed to heat.  |  Al-Mamun, M., et al. 2017. Animal. 11: 1287-1294. PMID: 28091361
  4. Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy.  |  Lu, M., et al. 2017. J Cereb Blood Flow Metab. 37: 3518-3530. PMID: 28503999
  5. Sweet taste receptor inhibitors: Potential treatment for equine insulin dysregulation.  |  de Laat, MA., et al. 2018. PLoS One. 13: e0200070. PMID: 29958298
  6. A Comparative Analysis of Methods for Quantitation of Sugars during the Corn-to-Ethanol Fermentation Process.  |  Bilskey, SR., et al. 2020. SLAS Technol. 25: 494-504. PMID: 32111129
  7. New Stable Cell Lines Derived from the Proximal and Distal Intestine of Rainbow Trout (Oncorhynchus mykiss) Retain Several Properties Observed In Vivo.  |  Pasquariello, R., et al. 2021. Cells. 10: PMID: 34205481
  8. Proton/Deuterium Magnetic Resonance Imaging of Rodents at 9.4T Using Birdcage Coils.  |  Zhang, Y., et al. 2022. Bioelectromagnetics. 43: 40-46. PMID: 34888902
  9. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status - A pilot study combining PET and deuterium metabolic imaging.  |  Meerwaldt, AE., et al. 2023. J Cereb Blood Flow Metab. 43: 778-790. PMID: 36606595
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  12. Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy.  |  Pehling, G., et al. 1984. J Clin Invest. 74: 985-91. PMID: 6381541
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Glucose-6,6-d2, 500 mg

sc-257287
500 mg
$99.00

D-Glucose-6,6-d2, 1 g

sc-257287A
1 g
$138.00

D-Glucose-6,6-d2, 10 g

sc-257287B
10 g
$1234.00

D-Glucose-6,6-d2, 100 g

sc-257287C
100 g
$10210.00