Molecular structure of Cytochalasin J, CAS Number: 53760-20-6
Cytochalasin J (CAS 53760-20-6)
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Application:
Cytochalasin J is a cell-permeable fungal toxin used in actin polymerization studies and cytological research
CAS Number:
53760-20-6
Purity:
>95%
Molecular Weight:
451.6
Molecular Formula:
C28H37NO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cytochalasin J is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. These fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. Cytochalasin J is the deacetyl analogue of cytochalasin H (sc-202119) and exhibits similar, though less potent, antibacterial, antifungal, nematocidal and antitumor activities.
Cytochalasin J (CAS 53760-20-6) References
- The effect of cytochalasin J on kinetochore structure in PtK1 cells is mitotic cycle dependent. | Wrench, GA. and Snyder, JA. 2001. Cell Biol Int. 25: 815-20. PMID: 11482906
- Redistribution of motor proteins by Cytochalasin J treatment. | Robinson, RW. and Snyder, JA. 2003. Cell Biol Int. 27: 665-73. PMID: 12867158
- Direct block of cloned hKv1.5 channel by cytochalasins, actin-disrupting agents. | Choi, BH., et al. 2005. Am J Physiol Cell Physiol. 289: C425-36. PMID: 15800051
- Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells. | Robinson, RW. and Snyder, JA. 2006. Cell Biol Int. 30: 631-9. PMID: 16731011
- Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa. | Xu, S., et al. 2009. Chem Biodivers. 6: 739-45. PMID: 19479839
- Both actin and myosin inhibitors affect spindle architecture in PtK1 cells: does an actomyosin system contribute to mitotic spindle forces by regulating attachment and movements of chromosomes in mammalian cells? | Snyder, JA., et al. 2010. Protoplasma. 240: 57-68. PMID: 20091066
- Induction of apoptosis against cancer cell lines by four ascomycetes (endophytes) from Malaysian rainforest. | Hazalin, NA., et al. 2012. Phytomedicine. 19: 609-17. PMID: 22397996
- Effects of cytochalasin and phalloidin on actin. | Cooper, JA. 1987. J Cell Biol. 105: 1473-8. PMID: 3312229
- In silico investigation on the inhibitory effect of fungal secondary metabolites on RNA dependent RNA polymerase of SARS-CoV-II: A docking and molecular dynamic simulation study. | Ebrahimi, KS., et al. 2021. Comput Biol Med. 135: 104613. PMID: 34242870
- Unreported cytochalasins from an acid-mediated transformation of cytochalasin J isolated from Diaporthe cf. ueckeri. | Kemkuignou, BM., et al. 2023. Fitoterapia. 166: 105434. PMID: 36681097
- Cytochalasin J affects chromosome congression and spindle microtubule organization in PtK1 cells. | Snyder, JA. and Cohen, L. 1995. Cell Motil Cytoskeleton. 32: 245-57. PMID: 8608604
- Cytochalasin J treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in PtK1 cells. | Wrench, GA. and Snyder, JA. 1997. Cell Motil Cytoskeleton. 36: 112-24. PMID: 9015200
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytochalasin J, 1 mg | sc-202120 | 1 mg | $120.00 |