CYP2B1/2B2 Antibody (b/e4): sc-53243
- CYP2B1/2B2 Antibody (b/e4) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against liver cytochromes P450 2B1 and 2B2 of rat origin
- recommended for detection of CYP2B1 and CYP2B2 of mouse and rat origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CYP2B1/2B2 Antibody (b/e4). This work is in progress.
CYP2B1/2B2 Antibody (b/e4) is a mouse monoclonal IgG1 antibody that detects CYP2B1/2B2 in mouse and rat samples through western blotting (WB). CYP2B1 and CYP2B2 are crucial members of the cytochrome P450 (CYP2) superfamily, which plays a significant role in the metabolism of various endogenous and exogenous compounds, including therapeutic agents and fatty acids. These enzymes are primarily located in the liver, where they facilitate the oxidation of substances, thereby influencing drug metabolism and detoxification processes. The liver′s central role in drug metabolism makes CYP2B1 and CYP2B2′s cellular location particularly significant, as their activity can substantially affect the pharmacokinetics of numerous medications. CYP2B1 converts ifosfamide into active cytotoxic metabolites, while CYP2B2 is involved in phenobarbital induction, highlighting their roles in both therapeutic efficacy and potential drug interactions. Anti-CYP2B1/2B2 antibody (b/e4) serves as an essential tool for researchers studying drug metabolism, liver function, and biochemical pathways involving these critical enzymes.
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CYP2B1/2B2 Antibody (b/e4) References:
- Phosphorylation/Dephosphorylation steps are crucial for the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital. | Kawamura, A., et al. 1999. Biochem Biophys Res Commun. 264: 530-6. PMID: 10529397
- Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing CYP2E1 by nicotine: summary and implications. | Schoedel, KA. and Tyndale, RF. 2003. Biochim Biophys Acta. 1619: 283-90. PMID: 12573488
- Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6, and CYP3A1. | Omiecinski, CJ., et al. 1990. Mol Pharmacol. 38: 462-70. PMID: 2233688
- Maternal protein restriction during lactation modulated the expression and activity of rat offspring hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2, and CYP2E1 during development. | Da Costa, NM., et al. 2016. Braz J Med Biol Res. 49: e5238. PMID: 27828666
- Phenobarbital induction of CYP2B1, CYP2B2, and CYP3A1 in rat liver: genetic differences in a common regulatory mechanism. | Larsen, MC. and Jefcoate, CR. 1995. Arch Biochem Biophys. 321: 467-76. PMID: 7646073
- Picrotoxin as a potent inducer of rat hepatic cytochrome P450, CYP2B1 and CYP2B2. | Yamada, H., et al. 1993. Biochem Pharmacol. 45: 1783-9. PMID: 8494537
- Transcriptional regulation of the CYP2B1 and CYP2B2 genes by C/EBP-related proteins. | Luc, PV., et al. 1996. Biochem Pharmacol. 51: 345-56. PMID: 8573202
- Phenobarbital induction of hepatic CYP2B1 and CYP2B2: pretranscriptional and post-transcriptional effects of gender, adult age, and phenobarbital dose. | Agrawal, AK. and Shapiro, BH. 1996. Mol Pharmacol. 49: 523-31. PMID: 8643092
- Promoter region analysis of the rat CYP2B1 and CYP2B2 genes. | Sommer, KM., et al. 1996. Pharmacogenetics. 6: 369-74. PMID: 8873225
- Insulin suppresses the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes. | Yoshida, Y., et al. 1996. Biochem Biophys Res Commun. 229: 182-8. PMID: 8954103
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CYP2B1/2B2 Antibody (b/e4) | sc-53243 | 200 µg/ml | $322.00 |