Cyclo(L-Phe-D-Pro)
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Cyclo(L-Phe-D-Pro) is a dipeptide compound that functions as a molecular scaffold in peptide chemistry. It may play a role in stabilizing the conformation of peptides and proteins, particularly in the design and synthesis of bioactive compounds. Cyclo(L-Phe-D-Pro) ′s mechanism of action involves influencing the spatial arrangement of amino acid residues, thereby affecting the structure and function of the peptide or protein. Cyclo(L-Phe-D-Pro) is utilized in applications to explore the impact of conformational constraints on the biological activity of peptides,. Cyclo(L-Phe-D-Pro) interacts with the peptide backbone, influencing its folding pattern and potentially altering its binding affinity or enzymatic activity. Cyclo(L-Phe-D-Pro)′s functional role in experimental applications lies in its ability to modulate the conformational flexibility of peptides, contributing to the study of structure-activity relationships in bioactive molecules.
Cyclo(L-Phe-D-Pro) References
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- Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold. | Bojarska, J., et al. 2021. Biomolecules. 11: PMID: 34680148
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- Mining Small Molecules from Teredinibacter turnerae Strains Isolated from Philippine Teredinidae. | Villacorta, JB., et al. 2022. Metabolites. 12: PMID: 36422292
- Identification of a novel secreted metabolite cyclo(phenylalanyl-prolyl) from Batrachochytrium dendrobatidis and its effect on Galleria mellonella. | Starr, AM., et al. 2022. BMC Microbiol. 22: 293. PMID: 36482304
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- N‐Acyl‐diketopiperazines: II. Crystal structure and conformation of N‐(pyruvoyl)‐cyclo‐(L‐phenylalanyl‐D‐prolyl) | ANNACALCAGNI, MAZZA, F., POCHETTI, G., ROSSI, D., & LUCENTE, G. 1985. International Journal of Peptide and Protein Research. 26(2): 166-173.
- Effects of steric bulk and stereochemistry on the rates of diketopiperazine formation from N-aminoacyl-2, 2-dimethylthiazolidine-4-carboxamides (Dmt dipeptide amides)-a model for a new prodrug linker system. | Suaifan, G. A., Mahon, M. F., Arafat, T., & Threadgill, M. D. 2006. Tetrahedron. 62(48): 11245-11266.
- L-Proline-based-cyclic dipeptides from Pseudomonas sp.(ABS-36) inhibit pro-inflammatory cytokines and alleviate crystal-induced renal injury in mice | Ahil, S. B., Hira, K., Shaik, A. B., Pal, P. P., Kulkarni, O. P., Araya, H., & Fujimoto, Y. 2019. International Immunopharmacology. 73: 395-404.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclo(L-Phe-D-Pro), 250 mg | sc-506240 | 250 mg | $326.00 |