Molecular structure of Cyamemazine, CAS Number: 3546-03-0
Cyamemazine (CAS 3546-03-0)
CAS Number:
3546-03-0
Purity:
98%
Molecular Weight:
323.46
Molecular Formula:
C19H21N3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Cyamemazine is a phenothiazine derivative which functions as a D2DR (dopamine D2 receptor) antagonist. Studies also indicate that Cyamemazine strongly antagonizes the 5-HT3 and SR-2C (5-HT2C) serotonin receptors. It is known that Cyamemazine functions as an alpha1 -adrenergic, H1, and mACh antagonist. Alternate studies indicate that Cyamemazine increases phototoxicity and lipid membrane peroxidation in cells and lysosomes. Cyamemazine can be detected in solution with a maximum absorbance of 267 nm. Furthermore, it is believed that Cyamemazine can inhibit the 9-hydroxylation of risperidone (sc-204881) and possibly an inhibitor of CYP2D6 (cytochrome P450 2D6).
Cyamemazine (CAS 3546-03-0) References
- Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice. | Bourin, M., et al. 2001. Behav Brain Res. 124: 87-95. PMID: 11423169
- Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. | Hameg, A., et al. 2003. Biochem Pharmacol. 65: 435-40. PMID: 12527336
- An insight into the mechanisms of the phototoxic response induced by cyamemazine in cultured fibroblasts and keratinocytes. | Morlière, P., et al. 2004. Photochem Photobiol. 79: 163-71. PMID: 15068029
- Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome. | Bourin, M., et al. 2004. CNS Drug Rev. 10: 219-29. PMID: 15492772
- Effects of cyamemazine on hERG, INa, ICa, Ito, Isus and IK1 channel currents, and on the QTc interval in guinea pigs. | Crumb, W., et al. 2006. Eur J Pharmacol. 532: 270-8. PMID: 16494862
- Affinity of cyamemazine metabolites for serotonin, histamine and dopamine receptor subtypes. | Benyamina, A., et al. 2008. Eur J Pharmacol. 578: 142-7. PMID: 17936750
- Cyamemazine metabolites: effects on human cardiac ion channels in-vitro and on the QTc interval in guinea pigs. | Crumb, W., et al. 2008. J Pharm Pharmacol. 60: 1507-13. PMID: 18957172
- Effect of cyamemazine on the steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: a preliminary retrospective study. | Lancelin, F., et al. 2010. Ther Drug Monit. 32: 757-61. PMID: 21068648
- Potential role of cortical 5-HT(2A) receptors in the anxiolytic action of cyamemazine in benzodiazepine withdrawal. | Benyamina, A., et al. 2012. Psychiatry Res. 198: 307-12. PMID: 22421069
- Photoallergic reaction to cyamemazine. | Fernandes, IC., et al. 2013. Dermatol Online J. 19: 15. PMID: 23473285
- [Cyamemazine (Tercian®): Exploration of extrapyramidal syndrome cases contained in the French pharmacovigilance database]. | Khouri, C., et al. 2017. Therapie. 72: 345-350. PMID: 27726885
- [Therapeutic drug monitoring of cyamemazine: How to interpret a concentration? A review of literature]. | Alarcan, H., et al. 2022. Therapie. 77: 603-609. PMID: 35221129
- Cyamemazine decreases ethanol intake in rats and convulsions during ethanol withdrawal syndrome in mice. | Naassila, M., et al. 1998. Psychopharmacology (Berl). 140: 421-8. PMID: 9888617
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyamemazine, 25 mg | sc-211144 | 25 mg | $408.00 |