CRY2 Antibody (181J2J): sc-517631
- CRY2 Antibody (181J2J) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against recombinant CRY2 of human origin
- recommended for detection of CRY2 of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CRY2 Antibody (181J2J). This work is in progress.
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CRY2 Antibody (181J2J) is a mouse monoclonal IgG1 antibody that detects CRY2 in mouse, rat, and human samples through western blotting (WB). CRY2, or cryptochrome 2, plays a crucial role in the regulation of circadian rhythms by acting as a light-independent inhibitor of the circadian clock. Located primarily in the nucleus, CRY2 interacts with various transcription factors, including Clock and BMAL1, to modulate their activity and maintain the balance of the circadian cycle. This interaction is vital for the proper functioning of the suprachiasmatic nucleus (SCN), the brain′s master clock, which orchestrates physiological processes such as sleep-wake cycles and hormonal rhythms. By forming heterodimers with PER proteins, CRY2 helps to establish a negative feedback loop that is essential for the timing and stability of circadian rhythms. CRY2′s ability to regulate these processes underscores its importance in maintaining overall health and well-being, as disruptions in circadian rhythms can lead to various health issues, including sleep disorders and metabolic syndromes. Anti-CRY2 antibody (181J2J) is an invaluable tool for researchers studying the intricate mechanisms of circadian biology.
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CRY2 Antibody (181J2J) References:
- CRY2 and FBXL3 Cooperatively Degrade c-MYC. | Huber, AL., et al. 2016. Mol Cell. 64: 774-789. PMID: 27840026
- Understanding CRY2 interactions for optical control of intracellular signaling. | Duan, L., et al. 2017. Nat Commun. 8: 547. PMID: 28916751
- CRY2 missense mutations suppress P53 and enhance cell growth. | Chan, AB., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34183418
- CRY2 interacts with CIS1 to regulate thermosensory flowering via FLM alternative splicing. | Zhao, Z., et al. 2022. Nat Commun. 13: 7045. PMID: 36396657
- Two determinants influence CRY2 photobody formation and function. | Ma, L., et al. 2023. Plant Biotechnol J. 21: 460-462. PMID: 36514885
- Loss of CRY2 promotes regenerative myogenesis by enhancing PAX7 expression and satellite cell proliferation. | Hao, Y., et al. 2023. MedComm (2020). 4: e202. PMID: 36636367
- Expression of CRY2 Gene in the Brain Is Related to Human Navigation. | Xu, S., et al. 2021. Front Radiol. 1: 731070. PMID: 37492180
- Transcription Repression of CRY2 via PER2 Interaction Promotes Adipogenesis. | Li, W., et al. 2023. Mol Cell Biol. 43: 500-514. PMID: 37724597
- Bao Yuan decoction alleviates fatigue by restraining inflammation and oxidative stress via the AMPK/CRY2/PER1 signaling pathway. | Zheng, Y., et al. 2024. J Ethnopharmacol. 328: 118058. PMID: 38513778
- CRY2 mediates the cognitive decline induced by sleep deprivation in 5xFAD mice. | Luo, S., et al. 2024. PLoS One. 19: e0306930. PMID: 39012854
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRY2 Antibody (181J2J) | sc-517631 | 100 µg/ml | $322.00 |