CRMP-5 Antibody (CR-1): sc-58515
- CRMP-5 Antibody (CR-1) is a rat monoclonal IgG1 CRMP-5 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 369-564 of CRMP-5 of human origin
- CRMP-5 Antibody (CR-1) is recommended for detection of the C terminal region of CRMP-5 of mouse, rat, human and bovine origin by WB, IP and IF; non cross-reactive with other CRMP isoforms
- Anti-CRMP-5 Antibody (CR-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CRMP-5 Antibody (CR-1). This work is in progress.
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CRMP-5 Antibody (CR-1) is a rat monoclonal IgG1 antibody that detects CRMP-5 protein of mouse, rat, human, and bovine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). CRMP-5 (CR-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Collapsin response mediator proteins (CRMPs) play a crucial role in neuronal signaling, particularly in response to the axon guidance molecule Semaphorin 3A (SEMA3A), which is vital for proper neuronal development and connectivity. CRMP-5 is expressed in the filopodia of growth cones and in adult central and peripheral neurons, including synapses, highlighting CRMP-5′s importance in maintaining neuronal plasticity and differentiation. Notably, CRMPs expression is significantly downregulated in the adult brain, yet CRMPs persist in regions that require ongoing plasticity, making CRMPs essential for adaptive responses in the nervous system. Additionally, CRMP-5 has been implicated in paraneoplastic syndromes, as CRMP-5 autoantibody (CRMP-5-IgG) is associated with small-cell lung carcinoma and thymoma, underscoring CRMP-5′s relevance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CRMP-5 Antibody (CR-1) References:
- CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. | Yu, Z., et al. 2001. Ann Neurol. 49: 146-54. PMID: 11220734
- Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung. | Thambisetty, MR., et al. 2001. J Neuroophthalmol. 21: 164-7. PMID: 11725180
- Subcellular localization of collapsin response mediator proteins to lipid rafts. | Rosslenbroich, V., et al. 2003. Biochem Biophys Res Commun. 305: 392-9. PMID: 12745088
- Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. | Cross, SA., et al. 2003. Ann Neurol. 54: 38-50. PMID: 12838519
- Paraneoplastic movement disorder in a patient with non-Hodgkin's lymphoma and CRMP-5 autoantibody. | Samii, A., et al. 2003. Mov Disord. 18: 1556-8. PMID: 14673901
- Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. | Quach, TT., et al. 2004. Mol Cell Neurosci. 25: 433-43. PMID: 15033171
- Critical role of collapsin response mediator protein-associated molecule CRAM for filopodia and growth cone development in neurons. | Hotta, A., et al. 2005. Mol Biol Cell. 16: 32-9. PMID: 15509652
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRMP-5 Antibody (CR-1) | sc-58515 | 200 µg/ml | $316.00 | |||
CRMP-5 Antibody (CR-1) AC | sc-58515 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CRMP-5 Antibody (CR-1) HRP | sc-58515 HRP | 200 µg/ml | $316.00 | |||
CRMP-5 Antibody (CR-1) FITC | sc-58515 FITC | 200 µg/ml | $330.00 | |||
CRMP-5 Antibody (CR-1) PE | sc-58515 PE | 200 µg/ml | $343.00 | |||
CRMP-5 Antibody (CR-1) Alexa Fluor® 488 | sc-58515 AF488 | 200 µg/ml | $357.00 | |||
CRMP-5 Antibody (CR-1) Alexa Fluor® 546 | sc-58515 AF546 | 200 µg/ml | $357.00 | |||
CRMP-5 Antibody (CR-1) Alexa Fluor® 594 | sc-58515 AF594 | 200 µg/ml | $357.00 | |||
CRMP-5 Antibody (CR-1) Alexa Fluor® 647 | sc-58515 AF647 | 200 µg/ml | $357.00 | |||
CRMP-5 Antibody (CR-1) Alexa Fluor® 680 | sc-58515 AF680 | 200 µg/ml | $357.00 | |||
CRMP-5 Antibody (CR-1) Alexa Fluor® 790 | sc-58515 AF790 | 200 µg/ml | $357.00 |