Corin Antibody (5B6): sc-293360

Corin Antibody (5B6) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Corin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Corin antibody (5B6) is available as the non-conjugated form. Corin, also known as atrial natriuretic peptide-converting enzyme, is a crucial serine protease that plays a significant role in cardiovascular homeostasis by converting pro-atrial natriuretic peptide (Pro-ANP) into its active form, ANP. This conversion is vital as ANP is involved in regulating blood pressure and fluid balance, thus influencing conditions such as hypertension and heart failure. Corin is primarily localized to the membrane as a single-pass type II membrane protein, where Corin interacts with atrial and brain natriuretic peptides (ANP and BNP) to facilitate their biological functions. The extracellular domain of Corin is structurally complex, containing two frizzled-like cysteine-rich domains, eight low-density lipoprotein receptor repeats, a macrophage scavenger receptor-like domain, and a trypsin-like protease domain at the C-terminus, which are essential for substrate recognition and enzymatic activity. Notably, the frizzled 1 domain and the first four LDLR repeats are critical for the recognition of Pro-ANP, allowing Corin to cleave between arginine 123 and serine 124, thereby activating ANP. Corin is predominantly expressed in cardiomyocytes, and studies have shown that mice lacking Corin develop hypertension and cardiac hypertrophy, underscoring its importance in cardiovascular health.

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Corin Antibody (5B6) References:

1. Rat corin gene: molecular cloning and reduced expression in experimental heart failure.  |  Langenickel, TH., et al. 2004. Am J Physiol Heart Circ Physiol. 287: H1516-21. PMID: 15155264
2. Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium.  |  Tran, KL., et al. 2004. Am J Physiol Heart Circ Physiol. 287: H1625-31. PMID: 15191894
3. Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide.  |  Knappe, S., et al. 2004. J Biol Chem. 279: 34464-71. PMID: 15192093
4. Hypertension in mice lacking the proatrial natriuretic peptide convertase corin.  |  Chan, JC., et al. 2005. Proc Natl Acad Sci U S A. 102: 785-90. PMID: 15637153
5. Changes in production and metabolism of brain natriuretic peptide in rats with myocardial necrosis.  |  Jiang, W., et al. 2005. Eur J Pharmacol. 507: 153-62. PMID: 15659305
6. Partial purification and characterization of pro-phospholipase A2 activating proteases from gill membranes of the red sea bream, Chrysophrys major.  |  Uchiyama, S. and Iijima, N. 2005. Comp Biochem Physiol B Biochem Mol Biol. 141: 121-7. PMID: 15820142
7. Serine proteases and cardiac function.  |  Wu, Q., et al. 2005. Biochim Biophys Acta. 1751: 82-94. PMID: 16054020
8. Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.  |  Dries, DL., et al. 2005. Circulation. 112: 2403-10. PMID: 16216958