connexin 32 Antibody (CXN-32): sc-59948

Connexin 32 Antibody (CXN-32) is a mouse monoclonal IgG1 antibody that detects connexin 32 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-connexin 32 antibody (CXN-32) is available as a non-conjugated format. Connexin 32 protein plays a crucial role in forming gap junctions, specialized intercellular channels allowing direct transfer of ions and small molecules between adjacent cells. This function maintains cellular communication and homeostasis, particularly in nervous system and liver tissues where coordinated activity is essential for proper physiological function. Connexin 32 structure, characterized by four transmembrane alpha-helical domains, two extracellular loops, and a cytoplasmic loop, enables functional connexon formation. Each connexin isoform, including connexin 32, exhibits unique properties influencing channel permeability and gating, critical for regulating intercellular signaling. Disruptions in connexin 32 expression or function can lead to significant pathological conditions, such as Charcot-Marie-Tooth disease, highlighting connexin 32′s importance in both health and disease.

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connexin 32 Antibody (CXN-32) References:

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