Clozapine N-oxide CAS: 34233-69-7
MF: C18H19ClN4O
MW: 342.82
A major metabolite of Clozapine noted to decrease 5-HT2 serotonin receptor density.

Clozapine N-oxide (CAS 34233-69-7)

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Application: Clozapine N-oxide is a major metabolite of Clozapine noted to decrease 5-HT2 serotonin receptor density
CAS Number: 34233-69-7
Molecular Weight: 342.82
Molecular Formula: C18H19ClN4O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Clozapine N-oxide is a major metabolite of Clozapine (sc-200402) noted to decrease 5-HT2 serotonin receptor density in vitro. In studies with in vitro human liver microsomal preparations, Clozapine was observed to metabolize to N-Desmethyl Clozapine (sc-219117) and N-oxide Clozapine. Clozapine N-oxide was noted to decrease 5-HT2 serotonin receptor density in rat primary cortical cells and human hippocampal SHS5Y5 neuroblastoma cells. As a method of identification, reversed-phase HPLC has been reported to be effective in identifying Clozapine and its two major metabolites.

Physical State :
Solid
Solubility :
Soluble in DMSO (9.8-10.2 mg/ml), ethanol (25 mg/ml), water (5 mg/ml), methanol, acetone, and ether.
Storage :
Store at -20° C
Melting Point :
255-260° C (dec.)
pK Values :
pKb: 6.86 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HP1760000
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
2819
MDL Number :
MFCD00210190
SMILES :
C[N+]1(CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl)[O-]

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Certificate of Analysis

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Clozapine N-oxide (CAS 34233-69-7)  Product Citations

See how others have used Clozapine N-oxide (CAS 34233-69-7). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25609622  Huckstepp, RT. et al. 2015. J. Neurosci. 35: 1052-67.

PMID: # 21394453  Wohlfarth, A. et al. 2011. Anal Bioanal Chem. 400: 737-46.

Citations 1 to 2 of 2 total
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