Clozapine N-oxide is a major metabolite of Clozapine (sc-200402) noted to decrease 5-HT2 serotonin receptor density in vitro. In studies with in vitro human liver microsomal preparations, Clozapine was observed to metabolize to N-Desmethyl Clozapine (sc-219117) and N-oxide Clozapine. Clozapine N-oxide was noted to decrease 5-HT2 serotonin receptor density in rat primary cortical cells and human hippocampal SHS5Y5 neuroblastoma cells. As a method of identification, reversed-phase HPLC has been reported to be effective in identifying Clozapine and its two major metabolites.
See how others have used Clozapine N-oxide (CAS 34233-69-7). Click on the entry to view the PubMed entry .
PMID: # 25609622 Huckstepp, RT. et al. 2015. J. Neurosci. 35: 1052-67.
PMID: # 21394453 Wohlfarth, A. et al. 2011. Anal Bioanal Chem. 400: 737-46.
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