Molecular structure of Clozapine N-oxide, CAS Number: 34233-69-7
Clozapine N-oxide (CAS 34233-69-7)
See product citations (8)
Application:
Clozapine N-oxide is a major metabolite of Clozapine noted to decrease 5-HT2 serotonin receptor density
CAS Number:
34233-69-7
Molecular Weight:
342.82
Molecular Formula:
C18H19ClN4O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Clozapine N-oxide is a major metabolite of clozapine (sc-200402), along with N-desmethyl clozapine (sc-219117), as identified by reverse-phase HPLC. It has been noted to decrease 5-HT2 serotonin receptor (SR-2A) density in rat primary cortical cells and human hippocampal SHS5Y5 neuroblastoma cells in vitro.
Clozapine N-oxide (CAS 34233-69-7) References
- Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats. | Saund, J., et al. 2017. Psychopharmacology (Berl). 234: 2399-2407. PMID: 28451710
- Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure. | Garrott, K., et al. 2017. Cardiovasc Res. 113: 1318-1328. PMID: 28472396
- Lateral thalamic control of nociceptive response after whisker pad injection of varicella zoster virus. | Kramer, PR., et al. 2017. Neuroscience. 356: 207-216. PMID: 28549561
- Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus. | Campos, CA., et al. 2017. Nat Neurosci. 20: 934-942. PMID: 28581479
- Memory Retention Involves the Ventrolateral Orbitofrontal Cortex: Comparison with the Basolateral Amygdala. | Zimmermann, KS., et al. 2018. Neuropsychopharmacology. 43: 373-383. PMID: 28664926
- DREADD-induced silencing of the medial amygdala reduces the preference for male pheromones and the expression of lordosis in estrous female mice. | McCarthy, EA., et al. 2017. Eur J Neurosci. 46: 2035-2046. PMID: 28677202
- Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours. | Koga, K., et al. 2017. Sci Rep. 7: 4739. PMID: 28680103
- Tg(Th-Cre)FI172Gsat (Th-Cre) defines neurons that are required for full hypercapnic and hypoxic reflexes. | Sun, JJ. and Ray, RS. 2017. Biol Open. 6: 1200-1208. PMID: 28684394
- Social Control of Hypothalamus-Mediated Male Aggression. | Yang, T., et al. 2017. Neuron. 95: 955-970.e4. PMID: 28757304
- Chemogenetics revealed: DREADD occupancy and activation via converted clozapine. | Gomez, JL., et al. 2017. Science. 357: 503-507. PMID: 28774929
- Chemogenetic activation of the lateral hypothalamus reverses early life stress-induced deficits in motivational drive. | Campbell, EJ., et al. 2017. Eur J Neurosci. 46: 2285-2296. PMID: 28858406
- Selective Pharmacogenetic Activation of Catecholamine Subgroups in the Ventrolateral Medulla Elicits Key Glucoregulatory Responses. | Li, AJ., et al. 2018. Endocrinology. 159: 341-355. PMID: 29077837
- Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity. | Shi, X., et al. 2017. Mol Metab. 6: 1350-1359. PMID: 29107283
- Activation of endogenous arginine vasopressin neurons inhibit food intake: by using a novel transgenic rat line with DREADDs system. | Yoshimura, M., et al. 2017. Sci Rep. 7: 15728. PMID: 29146932
- Eye-Drops for Activation of DREADDs. | Keenan, WT., et al. 2017. Front Neural Circuits. 11: 93. PMID: 29218003
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clozapine N-oxide, 5 mg | sc-391002 | 5 mg | $172.00 | |||
Clozapine N-oxide, 5 mg | sc-391002-CW | 5 mg | $322.00 | |||
Clozapine N-oxide, 25 mg | sc-391002A | 25 mg | $478.00 | |||
Clozapine N-oxide, 50 mg | sc-391002B | 50 mg | $853.00 |