Date published: 2026-5-9

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Clorexolone (CAS 2127-01-7)

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CAS Number:
2127-01-7
Purity:
≥98%
Molecular Weight:
328.81
Molecular Formula:
C14H17ClN2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Clorexolone is a synthetic chemical compound that has been the subject of various scientific studies, particularly focusing on its chemical structure and reactivity in non-biological systems. The compound is characterized by a chlorinated aromatic ring, which is a key functional group influencing its chemical behavior and interactions. In research, Clorexolone is often used to study the effects of halogenation on the stability and reactivity of aromatic compounds. Halogen atoms, like chlorine, attached to an aromatic ring can significantly alter the electronic properties of the molecule. This makes Clorexolone a useful model compound for understanding electrophilic substitution reactions, where the presence of the chlorine atom can either activate or deactivate the ring towards further substitution depending on the conditions and the type of reaction being studied. Furthermore, the study of Clorexolone in non-biological systems provides insights into the physicochemical properties of chlorinated aromatics, such as solubility, volatility, and interaction with solvents. These studies are crucial for developing a comprehensive understanding of how such compounds behave in different chemical environments, which can inform their handling, storage, and disposal in industrial settings.


Clorexolone (CAS 2127-01-7) References

  1. HYPOTENSIVE ACTION OF HYDROCHLOROTHIAZIDE AND CLOREXOLONE IN THE CONSCIOUS NORMOTENSIVE DOG.  |  MAXWELL, DR. and MCLUSKY, JM. 1964. Nature. 202: 300-1. PMID: 14167796
  2. A PHARMACOLOGY TEACHING EXERCISE IN DRUG EVALUATION: A COMPARISON OF THE DIURETIC EFFICACY OF CLOREXOLONE, HYDROCHLOROTHIAZIDE AND A PLACEBO IN NORMAL SUBJECTS.  |  BLOOMFIELD, SS. and TETREAULT, L. 1965. Can Med Assoc J. 92: 662-5. PMID: 14269436
  3. First-line combination therapy versus first-line monotherapy for primary hypertension.  |  Garjón, J., et al. 2020. Cochrane Database Syst Rev. 2: CD010316. PMID: 32026465
  4. Thiazide diuretics alone or in combination with a potassium-sparing diuretic on blood pressure-lowering in patients with primary hypertension: protocol for a systematic review and network meta-analysis.  |  Martins, VM., et al. 2022. Syst Rev. 11: 23. PMID: 35135630
  5. The diuretic activity of clorexolone and some related phthalimides and 1-oxoisoindolines.  |  Cornish, EJ., et al. 1966. J Pharm Pharmacol. 18: 65-80. PMID: 4380757
  6. Comparison of clorexolone, a new diuretic, with hydrochlorothiazide.  |  Russell, RP., et al. 1969. Clin Pharmacol Ther. 10: 265-71. PMID: 4887299
  7. On the clinical evaluation of diuretics with particular reference to a new phthalimidine diuretic, clorexolone.  |  Lant, AF., et al. 1966. Clin Pharmacol Ther. 7: 196-211. PMID: 5934250
  8. Studies on the mechanism and characteristics of action of a new phthalimidine diuretic, clorexolone.  |  Baba, WI., et al. 1966. Clin Pharmacol Ther. 7: 212-23. PMID: 5934251
  9. The antihypertensive effect of guanfacine compared with methyldopa.  |  van der Merwe, CJ. and Kruger, SA. 1980. S Afr Med J. 57: 400-4. PMID: 6105713
  10. Lithium and the antidiuretic hormone.  |  MacNeil, S., et al. 1976. Br J Clin Pharmacol. 3: 305-13. PMID: 788747

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Clorexolone, 5 mg

sc-353145
5 mg
$160.00