Clobenpropit Dihydrobromide, VUF 9153 CAS: 145231-45-4
MF: C14H17ClN4S 2HBr
MW: 470.65
A histamine H3 receptor antagonist.

Clobenpropit Dihydrobromide, VUF 9153 (CAS 145231-45-4)

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Application: A histamine H3 receptor antagonist
CAS Number: 145231-45-4
Purity: 99%
Molecular Weight: 470.65
Molecular Formula: C14H17ClN4S 2HBr
* Refer to Certificate of Analysis for lot specific data (including water content).
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Clobenpropit dihydrobromide, VUF 9153 has been shown to be an extremely potent (pA2 = 9.93) and selective histamine H3 receptor antagonist. This compound has been found to enhance the release of GABA, which protects against NMDA-induced exitotoxicity. Further experiments suggest that clobenpropit dihydrobromide my inhibit the binding of iodophenpropit, and therefor may possess the ability to cross the blood-brain barrier.


1. Yokoyama, H., et al. 1994. Eur. J. Pharmacol. 260: 23-28. PMID: 7957622
2. Harada, C., et al. 2004. Brain Res. Bull. 63: 143-146. PMID: 15130703
3. Dai, H., et al. 2007. Eur. J. Pharmacol. 563: 117-123. PMID: 17350613
4. Devi, P.U., et al. 2010. Hum Exp Toxicol. [Epub ahead of print]. PMID: 20511290

Physical State :
Solubility :
Readily Soluble in Water, DMSO and Ethanol.
Storage :
Store at 4° C
Melting Point :
215-216° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

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Certificate of Analysis

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