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Clindamycin sulfoxide (CAS 22431-46-5)

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Application:
Clindamycin sulfoxide is a Clindamycin metabolite
CAS Number:
22431-46-5
Molecular Weight:
440.98
Molecular Formula:
C18H33ClN2O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Clindamycin sulfoxide, an antibiotic, exerts its antimicrobial activity by specifically binding to the 50S ribosomal subunit and inhibiting protein synthesis. As an active metabolite of the antibiotic clindamycin, it is formed through the process of S-oxidation primarily by the cytochrome P450 (CYP) isoform CYP3A4. The study of clindamycin sulfoxide and similar antibiotic metabolites contributes to the fields of environmental science. Residues of antibiotics and their metabolites can enter the environment through various pathways. Understanding the stability, mobility, and ecological impacts of these compounds is essential for assessing their environmental footprint and developing measures to mitigate potential risks to ecosystems.


Clindamycin sulfoxide (CAS 22431-46-5) References

  1. In vitro metabolism of clindamycin in human liver and intestinal microsomes.  |  Wynalda, MA., et al. 2003. Drug Metab Dispos. 31: 878-87. PMID: 12814964
  2. Pharmacokinetics of clindamycin administered orally to pigeons.  |  Lenarduzzi, T., et al. 2011. J Avian Med Surg. 25: 259-65. PMID: 22458181
  3. Determination of clindamycin and its metabolite clindamycin sulfoxide in diverse sewage samples.  |  Oertel, R., et al. 2014. Environ Sci Pollut Res Int. 21: 11764-9. PMID: 24310902
  4. Simultaneous determination of most prescribed antibiotics in multiple urban wastewater by SPE-LC-MS/MS.  |  Rossmann, J., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 969: 162-70. PMID: 25171505
  5. Mass flow of antibiotics in a wastewater treatment plant focusing on removal variations due to operational parameters.  |  Marx, C., et al. 2015. Sci Total Environ. 538: 779-88. PMID: 26340581
  6. Bioavailability of Clindamycin From a New Clindamycin Phosphate 1.2%-Benzoyl Peroxide 3% Combination Gel.  |  Jones, TM., et al. 2013. Clin Pharmacol Drug Dev. 2: 33-47. PMID: 27121558
  7. Antibiotics degradation in soil: A case of clindamycin, trimethoprim, sulfamethoxazole and their transformation products.  |  Koba, O., et al. 2017. Environ Pollut. 220: 1251-1263. PMID: 27838062
  8. Transformation products of clindamycin in moving bed biofilm reactor (MBBR).  |  Ooi, GTH., et al. 2017. Water Res. 113: 139-148. PMID: 28213335
  9. Ways to Improve Insights into Clindamycin Pharmacology and Pharmacokinetics Tailored to Practice.  |  Armengol Álvarez, L., et al. 2022. Antibiotics (Basel). 11: PMID: 35625345
  10. Plasmodium berghei: uptake of clindamycin and its metabolites by mouse erythrocytes with clindamycin-sensitive and clindamycin-resistant parasites.  |  Koontz, LC., et al. 1979. Exp Parasitol. 48: 206-12. PMID: 383487
  11. Microbial transformation of antibiotics. V. Clindamycin ribonucleotides.  |  Argoudelis, AD. and Coats, JH. 1971. J Am Chem Soc. 93: 534-5. PMID: 5541521
  12. Clindamycin activity against chloroquine-resistant Plasmodium falciparum.  |  Seaberg, LS., et al. 1984. J Infect Dis. 150: 904-11. PMID: 6389719
  13. Microbial transformation of antibiotics. Clindamycin ribonucleotides.  |  Argoudelis, AD., et al. 1977. J Antibiot (Tokyo). 30: 474-87. PMID: 885808

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Clindamycin sulfoxide, 2.5 mg

sc-211115
2.5 mg
$302.00

your Clindamycin sulfoxide (CAS 22431-46-5) is R- or S- or a mixture of the diasteromers?

Asked by: jennifer_682
Thank you for your question about our biochemical, Clindamycin sulfoxide (CAS 22431-46-5): sc-211115. The compound that we sell is a mixture of diastereomers.
Answered by: Technical Support
Date published: 2016-10-17
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Rated 5 out of 5 by from Seaberg et alSeaberg et al. (PubMed ID 6389719) found that Clinidamycin sulfoxide treatment reduced protein and nucleic acid synthesis in Plasmodium falciparum. -SCBT Publication Review
Date published: 2015-05-13
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Clindamycin sulfoxide is rated 5.0 out of 5 by 1.
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