Molecular structure of Clindamycin Hydrochloride, CAS Number: 21462-39-5
Clindamycin Hydrochloride (CAS 21462-39-5)
See product citations (7)
Alternate Names:
U-21251F; Cleocin
Application:
Clindamycin Hydrochloride is a suppressor of protein synthesis in bacteria
CAS Number:
21462-39-5
Purity:
>95%
Molecular Weight:
461.44
Molecular Formula:
C18H33ClN2O5S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Clindamycin Hydrochloride is an antibiotic which inhibits bacterial protein synthesis and is concentration dependent. Sensitive organisms to Clindamycin are usually gram-positive cocci and many anaerobic bacteria. As an inhibitor of protein synthesis, Clindamycin Hydrochloride binds to the 50s ribosomal subunit and is reported to inhibit peptidyltransferase and therfore affecting the process of peptide chain initiation. Additionally reported to possibly stimulate the dissociation of peptidyl-tRNA from ribosomes, therefore inhibiting protein synthesis.
Clindamycin Hydrochloride (CAS 21462-39-5) References
- Clindamycin hydrochloride and clavulanate-amoxycillin in the treatment of canine superficial pyoderma. | Littlewood, JD., et al. 1999. Vet Rec. 144: 662-5. PMID: 10404604
- Efficacy of once-daily clindamycin hydrochloride in the treatment of superficial bacterial pyoderma in dogs. | Bloom, PB. and Rosser, EJ. 2001. J Am Anim Hosp Assoc. 37: 537-42. PMID: 11716027
- Bacterial ribosomal subunit synthesis: a novel antibiotic target. | Champney, WS. 2001. Curr Drug Targets Infect Disord. 1: 19-36. PMID: 12455231
- Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications. | Spízek, J., et al. 2004. Adv Appl Microbiol. 56: 121-54. PMID: 15566978
- Clindamycin bioavailability and pharmacokinetics following oral administration of clindamycin hydrochloride capsules in dogs. | Batzias, GC., et al. 2005. Vet J. 170: 339-45. PMID: 16266847
- Canine periodontal disease control using a clindamycin hydrochloride gel. | Johnston, TP., et al. 2011. J Vet Dent. 28: 224-9. PMID: 22416621
- Efficacy of clindamycin hydrochloride in refractory periodontitis: 24-month results. | Gordon, J., et al. 1990. J Periodontol. 61: 686-91. PMID: 2254835
- Development and optimization of taste-masked orally disintegrating tablets (ODTs) of clindamycin hydrochloride. | Cantor, SL., et al. 2015. Drug Dev Ind Pharm. 41: 1156-64. PMID: 25000481
- Preparation of Clindamycin Hydrochloride Loaded De-Esterified Low-Methoxyl Mango Peel Pectin Film Used as a Topical Drug Delivery System. | Chaiwarit, T., et al. 2020. Polymers (Basel). 12: PMID: 32349233
- Formulation and characterization of propolis and tea tree oil nanoemulsion loaded with clindamycin hydrochloride for wound healing: In-vitro and in-vivo wound healing assessment. | Abdellatif, MM., et al. 2021. Saudi Pharm J. 29: 1238-1249. PMID: 34819785
- Efficacy of clindamycin hydrochloride in refractory periodontitis. 12-month results. | Gordon, J., et al. 1985. J Periodontol. 56: 75-80. PMID: 3908641
- Systemic absorption of clindamycin hydrochloride after topical application. | Barza, M., et al. 1982. J Am Acad Dermatol. 7: 208-14. PMID: 6215432
- On the bioavailability of topical formulations of clindamycin hydrochloride. | Franz, TJ. 1983. J Am Acad Dermatol. 9: 66-73. PMID: 6886106
- A comparison of lincomycin hydrochloride and clindamycin hydrochloride in the treatment of superficial pyoderma in dogs. | Harvey, RG., et al. 1993. Vet Rec. 132: 351-3. PMID: 8488640
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clindamycin Hydrochloride, 20 mg | sc-200097 | 20 mg | $52.00 | |||
Clindamycin Hydrochloride, 100 mg | sc-200097A | 100 mg | $187.00 |