Clindamycin Hydrochloride CAS: 21462-39-5
MF: C18H33ClN2O5S•HCl
MW: 461.44
A suppressor of protein synthesis in bacteria.

Clindamycin Hydrochloride (CAS 21462-39-5)

Clindamycin Hydrochloride | CAS 21462-39-5 is rated 4.0 out of 5 by 1.
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Alternate Names: U-21251F; Cleocin
Application: Clindamycin Hydrochloride is a suppressor of protein synthesis in bacteria
CAS Number: 21462-39-5
Purity: >95%
Molecular Weight: 461.44
Molecular Formula: C18H33ClN2O5S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Clindamycin is an antibiotic which inhibits bacterial protein synthesis and is concentration dependent. Sensitive organisms to Clindamycin are usually gram-positive cocci and many anaerobic bacteria. As an inhibitor of protein synthesis, Clindamycin binds to the 50s ribosomal subunit and is reported to inhibit peptidyltransferase and therfore affecting the process of peptide chain initiation. Additionally reported to possibly stimulate the dissociation of peptidyl-tRNA from ribosomes, therefore inhibiting protein synthesis.


References

1. Champney, W.S., 2001. Curr Drug Targets Infect Disord. 1: 19-36. PMID: 12455231
2. Spízek, J., et al. 2004. Adv. Appl. Microbiol. 56: 121-154. PMID: 15566978

Physical State :
Solid
Solubility :
Soluble in water, alcohol and DMF.
Storage :
Store at -20° C
Melting Point :
141° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
GF2275000
PubChem CID :
16051951
MDL Number :
MFCD07793327
EC Number :
244-398-6
Beilstein Registry :
4070786

Download SDS (MSDS)

Certificate of Analysis

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Clindamycin Hydrochloride (CAS 21462-39-5)  Product Citations

See how others have used Clindamycin Hydrochloride (CAS 21462-39-5). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 16369001  Aduse-Opoku, J. et al. 2006. Infect. Immun. 74: 449-460.

PMID: # 16197708  Boot, R. et al. 2005. Lab. Anim. 39: 413-420.

PMID: # 10759399  Boot, R. et al. 1999. Lab. Anim. 33: 91-94.

PMID: # 8844572  Kamp, EM. et al. 1996. J. Vet. Diagn. Invest. 8: 304-309.

PMID: # 6842009  Wilson, KH. et al. 1983. J. Infect. Dis. 147: 733-736.

PMID: # 669820  Roberts, DW. et al. 1978. Infect. Immun. 20: 728-731.

Citations 1 to 6 of 6 total

Is this product made using biotechnology? In other words, is Clindamycin chemically synthesized or derived from natural sources? Thank you.

Asked by: Jan B
Thank you for your question. It's a semi-synthetic antibiotic and produced by the chlorination of Lincomycin while Lincomycin is produced by fermentation of Streptomyces lincolnensis mutant strain.
Answered by: Tech Service
Date published: 2020-01-22

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical is supplied as a white or yellowish powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-18
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Date published: 2015-04-20
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