Date published: 2026-4-24

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Clethodim (CAS 99129-21-2)

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Alternate Names:
2-{(E)-1-[(E)-3-Chloroallyloxyimino]propyl}-5-[2-(ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-one
CAS Number:
99129-21-2
Molecular Weight:
359.91
Molecular Formula:
C17H26ClNO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Clethodim is a colorless organic compound belonging to the cyclohexanedione family of herbicides. It serves as a systemic graminicide and post-emergent herbicide primarily targeting grasses, notably Lolium rigidum. While impure samples may exhibit a yellowish tint, the compound itself is colorless. Clethodim acts as an inhibitor of acetyl-coenzyme A carboxylase (ACCase), making it effective in controlling grass weed infestation in dicot crops.


Clethodim (CAS 99129-21-2) References

  1. Determination of clethodim and its oxidation metabolites in crops by liquid chromatography with confirmation by LC/MS.  |  Ishimitsu, S., et al. 2001. J AOAC Int. 84: 1172-8. PMID: 11501920
  2. Indirect photodegradation of clethodim in aqueous media. byproduct identification by quadrupole time-of-flight mass spectrometry.  |  Sevilla-Morán, B., et al. 2010. J Agric Food Chem. 58: 3068-76. PMID: 20128587
  3. Clethodim exposure induces developmental immunotoxicity and neurobehavioral dysfunction in zebrafish embryos.  |  Xiong, G., et al. 2019. Fish Shellfish Immunol. 86: 549-558. PMID: 30517881
  4. Herbicidal Activity and Molecular Docking Study of Novel ACCase Inhibitors.  |  Ye, F., et al. 2018. Front Plant Sci. 9: 1850. PMID: 30619418
  5. Clethodim exposure induced development toxicity and behaviour alteration in early stages of zebrafish life.  |  Wang, H., et al. 2019. Environ Pollut. 255: 113218. PMID: 31541821
  6. Resistance to clethodim in Italian ryegrass (Lolium perenne ssp. multiflorum) from Mississippi and North Carolina.  |  Nandula, VK., et al. 2020. Pest Manag Sci. 76: 1378-1385. PMID: 31613044
  7. Metabolic profile and behavior of clethodim and spirotetramat in herbs during plant growth and processing under controlled conditions.  |  Jankowska, M., et al. 2020. Sci Rep. 10: 1323. PMID: 31992750
  8. Clethodim (herbicide) alters the growth and toxins content of Microcystis aeruginosa and Raphidiopsis raciborskii.  |  Brêda-Alves, F., et al. 2020. Chemosphere. 243: 125318. PMID: 31995862
  9. Simultaneous Analysis and Dietary Exposure Risk Assessment of Fomesafen, Clomazone, Clethodim and Its Two Metabolites in Soybean Ecosystem.  |  Pang, K. and Hu, J. 2020. Int J Environ Res Public Health. 17: PMID: 32191999
  10. The combined effect of clethodim (herbicide) and nitrogen variation on allelopathic interactions between Microcystis aeruginosa and Raphidiopsis raciborskii.  |  Brêda-Alves, F., et al. 2021. Environ Sci Pollut Res Int. 28: 11528-11539. PMID: 33128150
  11. Simultaneous determination and dietary risk assessment of clethodim and its metabolites in different fruits and vegetables.  |  Atzei, A., et al. 2021. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 38: 830-841. PMID: 33784219
  12. ARTP Mutagenesis of Schizochytrium sp. PKU#Mn4 and Clethodim-Based Mutant Screening for Enhanced Docosahexaenoic Acid Accumulation.  |  Liu, L., et al. 2021. Mar Drugs. 19: PMID: 34677463
  13. Methomyl, imbraclaobrid and clethodim induced cytomixis and syncytes behaviors in PMCs of Pisum sativum L: Causes and outcomes.  |  Siddiqui, S. and Alrumman, SA. 2022. Saudi J Biol Sci. 29: 103390. PMID: 35935105

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Clethodim, 100 mg

sc-257259
100 mg
$168.00