Molecular structure of cis-trismethoxy Resveratrol, CAS Number: 94608-23-8
cis-trismethoxy Resveratrol (CAS 94608-23-8)
Alternate Names:
,3-dimethoxy-5-[(1Z)-2-(4-methoxyphenyl)ethenyl]-benzene
Application:
cis-trismethoxy Resveratrol is a potent antioxidant found in grapes and red wine
CAS Number:
94608-23-8
Purity:
≥98%
Molecular Weight:
270.3
Molecular Formula:
C17H18O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Resveratrol is a potent antioxidant found in grapes and red wine that also has anti-angiogenic, anti-proliferative and anti-neoplastic activities. In addition, resveratrol activates sirtuins1 and, in yeast, extends lifespan.2 This coumpound is a potent anti-mitotic drug that is 100-fold more active than resveratrol at inhibiting the growth of human colon cancer Caco-2 cells.3 It inhibits tubulin polymerization in a dose-dependent manner (IC50 = 4 μM) and inhibits enzymes involved in the synthesis of the polyamines, putrescine and spermidine.34 It has superior pharmacokinetic characteristics when compared with resveratrol, including greater plasma exposure, longer elimination half-life, and lower clearance.5
cis-trismethoxy Resveratrol (CAS 94608-23-8) References
1 Borra, M.T., Smith, B.C., Denu, J.M. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 280(17) 17187-17195 (2005). 2 Howitz, K.T., Bitterman, K.J., Cohen, H.Y., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 191-196 (2003). 3 Schneider, Y., Chabert, P., Stutzmann, J., et al. Resveratrol analog (Z)-3,5,4'-trimethoxystilbene is a potent anti-mitotic drug inhibiting tubulin polymerization. Int J Cancer 107 189-196 (2003). 4 Cushman, M., Nagarathnam, D., Gopal, D., et al. Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. J Med Chem 34 2579-2588 (1991). 5 Lin, H., Ho, P.C. A rapid HPLC method for the quantification of 3,5,4'-trimethoxy-trans-stilbene (TMS) in rat plasma and its application in pharmacokinetic study. J Pharm Biomed Analysis 49 387-392 (2009).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cis-trismethoxy Resveratrol, 10 mg | sc-205255 | 10 mg | $24.00 | |||
cis-trismethoxy Resveratrol, 50 mg | sc-205255A | 50 mg | $108.00 |