Date published: 2025-12-4

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cis-Aconitic anhydride (CAS 6318-55-4)

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Alternate Names:
cis-Propene-1,2,3-tricarboxylic anhydride
CAS Number:
6318-55-4
Purity:
≥94%
Molecular Weight:
156.09
Molecular Formula:
C6H4O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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cis-Aconitic anhydride is prominently used in organic synthesis research, where it acts as an intermediate in the synthesis of various organic compounds. Its reactivity with different chemicals under specific conditions allows researchers to explore and develop new synthetic pathways and chemical reactions. In polymer science, cis-Aconitic anhydride is explored for modifying the properties of biodegradable polymers, which are significant for advancing materials science. This chemical is also employed in studies related to the carbon-carbon bond formation processes, providing insights into more efficient and sustainable chemical synthesis techniques. Additionally, cis-Aconitic anhydride plays a role in biochemical studies, particularly in investigating the mechanisms of enzyme-catalyzed decarboxylation reactions, thus contributing to a deeper understanding of metabolic pathways in organisms.


cis-Aconitic anhydride (CAS 6318-55-4) References

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  2. Facile preparation of an orthogonally protected, pH-sensitive, bioconjugate linker for therapeutic applications.  |  Fletcher, S., et al. 2004. Org Lett. 6: 4245-8. PMID: 15524454
  3. Synthesis of poly(vinyl alcohol)-doxorubicin conjugates containing cis-aconityl acid-cleavable bond and its isomer dependent doxorubicin release.  |  Kakinoki, A., et al. 2008. Biol Pharm Bull. 31: 103-10. PMID: 18175951
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  5. Rod-like cellulose nanocrystal/cis-aconityl-doxorubicin prodrug: A fluorescence-visible drug delivery system with enhanced cellular uptake and intracellular drug controlled release.  |  Li, N., et al. 2018. Mater Sci Eng C Mater Biol Appl. 91: 179-189. PMID: 30033244
  6. Type of pH sensitive linker reveals different time-dependent intracellular localization, in vitro and in vivo efficiency in alpha-fetoprotein receptor targeted doxorubicin conjugate.  |  Mollaev, M., et al. 2019. Int J Pharm. 559: 138-146. PMID: 30599230
  7. Microenvironment-Induced In Situ Self-Assembly of Polymer-Peptide Conjugates That Attack Solid Tumors Deeply.  |  Cong, Y., et al. 2019. Angew Chem Int Ed Engl. 58: 4632-4637. PMID: 30695128
  8. One step bulk modification of poly(L-lactic acid) composites with functional additives to improve mechanical and biological properties for cardiovascular implant applications.  |  Kang, EY., et al. 2019. Colloids Surf B Biointerfaces. 179: 161-169. PMID: 30954879
  9. Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy.  |  Ding, J., et al. 2013. Biomater Sci. 1: 633-646. PMID: 32481836
  10. Spatiotemporal Concurrent Liberation of Cytotoxins from Dual-Prodrug Nanomedicine for Synergistic Antitumor Therapy.  |  Zhang, L., et al. 2021. ACS Appl Mater Interfaces. 13: 6053-6068. PMID: 33525873
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  12. pH and GSH dual-responsive drug-controlled nanomicelles for breast cancer treatment.  |  Xu, J., et al. 2023. Biomed Mater. 18: PMID: 36720160
  13. The structure and function of ribonuclease T1. XXIII. Inactivation of ribonuclease T1 by reversible blocking of amino groups with cis-aconitic anhydride and related dicarboxylic acid anhydrides.  |  Takahashi, K. 1977. J Biochem. 81: 641-6. PMID: 405378
  14. Preparation of four daunomycin-monoclonal antibody 791T/36 conjugates with anti-tumour activity.  |  Gallego, J., et al. 1984. Int J Cancer. 33: 737-44. PMID: 6376376
  15. Inhibition of influenza virus fusion by polyanionic proteins.  |  Schoen, P., et al. 1997. Biochem Pharmacol. 53: 995-1003. PMID: 9174113

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

cis-Aconitic anhydride, 1 g

sc-257252
1 g
$48.00