CINP Antibody (AT1G10): sc-517393

CINP Antibody (AT1G10) is a mouse monoclonal IgG1 kappa light chain antibody that detects CINP protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CINP antibody (AT1G10) is available as a non-conjugated format. Cyclin-dependent kinase 2-interacting protein (CINP) plays a crucial role in cell cycle regulation by interacting with key components of the replication complex, including Cdk2 and Cdc7. This interaction establishes a functional and physical link between these two kinases during DNA replication initiation, ensuring smooth cell cycle progression. CINP undergoes phosphorylation by Cdc7, which is essential for function, while remaining unphosphorylated by Cdk2. CINP also interacts with ATR-interacting protein, regulating ATR-dependent signaling pathways critical for maintaining resistance to replication stress and ensuring G2 checkpoint integrity. This multifaceted role of CINP underscores its importance in cell cycle regulation and genomic stability, making CINP monoclonal antibody (AT1G10) an invaluable research tool for studying these processes.

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CINP Antibody (AT1G10) References:

1. Cyclin-dependent kinases and S phase control in mammalian cells.  |  Woo, RA. and Poon, RY. 2003. Cell Cycle. 2: 316-24. PMID: 12851482
2. A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.  |  Grishina, I. and Lattes, B. 2005. Cell Cycle. 4: 1120-6. PMID: 16082200
3. Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases.  |  Montagnoli, A., et al. 2006. J Biol Chem. 281: 10281-90. PMID: 16446360
4. Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry.  |  Chuang, LC., et al. 2009. Mol Cell. 35: 206-16. PMID: 19647517
5. Functional genomic screens identify CINP as a genome maintenance protein.  |  Lovejoy, CA., et al. 2009. Proc Natl Acad Sci U S A. 106: 19304-9. PMID: 19889979
6. Differential Dynamics of ATR-Mediated Checkpoint Regulators.  |  Warmerdam, DO., et al. 2010. J Nucleic Acids. 2010: PMID: 20847938
7. Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle.  |  Hengstschläger, M., et al. 1999. Mutat Res. 436: 1-9. PMID: 9878675

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CINP Antibody (AT1G10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CINP Antibody (AT1G10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CINP Antibody (AT1G10) Specifications

Alternate Product Name: CINP

Product Clone Name: AT1G10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-212

Epitope Target: CINP

Epitope Species: human

Product Reactivity/Detection: CINP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 1% glycerol and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CINP Antibody (AT1G10): N/A