Choriogonadotropin Antibody (2092): sc-57054
- Choriogonadotropin Antibody (2092) is a mouse monoclonal IgG1 Choriogonadotropin antibody provided at 500 µl supernatant
- raised against Choriogonadotropin of human origin
- recommended for detection of Choriogonadotropin of human origin by IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Choriogonadotropin Antibody (2092). This work is in progress.
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Choriogonadotropin Antibody (2092) is a mouse monoclonal IgG1 antibody that detects the Choriogonadotropin protein of human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Choriogonadotropin antibody (2092) is available as the non-conjugated form. Choriogonadotropin, a crucial hormone produced by the placenta during the first trimester of pregnancy, plays a vital role in maintaining pregnancy by stimulating the ovaries to produce essential steroids such as estrogen and progesterone. This hormone exists as a heterodimer, composed of a unique β chain and an α chain that is common to all gonadotropins. The unique β chain is responsible for the biological specificity of choriogonadotropin, luteinizing hormone, and follicle-stimulating hormone. The α subunit is encoded by a gene located on human chromosome 6, while the β subunit is mapped to chromosome 19. The proper functioning of choriogonadotropin is critical, as choriogonadotropin ensures the maintenance of normal steroid levels necessary for a successful pregnancy. Additionally, choriogonadotropin belongs to the cystine knot growth-factor superfamily, characterized by a distinct arrangement of six cysteine residues, which is essential for structural integrity and biological activity. The secretion and dimerization of choriogonadotropin are influenced by the conformation of the cystine knot, although biological activity remains independent of this conformation, highlighting the complexity and importance of this protein in reproductive health.
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Choriogonadotropin Antibody (2092) References:
- Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. | Naylor, SL., et al. 1983. Somatic Cell Genet. 9: 757-70. PMID: 6581542
- The cystine-knot growth-factor superfamily. | Sun, PD. and Davies, DR. 1995. Annu Rev Biophys Biomol Struct. 24: 269-91. PMID: 7663117
- Mutagenesis of cysteine residues in the human gonadotropin alpha subunit. Roles of individual disulfide bonds in secretion, assembly, and biologic activity. | Furuhashi, M., et al. 1994. J Biol Chem. 269: 25543-8. PMID: 7929256
- Crystal structure of human chorionic gonadotropin. | Lapthorn, AJ., et al. 1994. Nature. 369: 455-61. PMID: 8202136
- Disulfide bonds 7-31 and 59-87 of the alpha-subunit play a different role in assembly of human chorionic gonadotropin and lutropin. | Furuhashi, M., et al. 1996. Endocrinology. 137: 4196-200. PMID: 8828477
- Cystine knot of the gonadotropin alpha subunit is critical for intracellular behavior but not for in vitro biological activity. | Sato, A., et al. 1997. J Biol Chem. 272: 18098-103. PMID: 9218442
- Regulation of prostaglandin F2alpha-receptor mRNA in human granulosa-luteal cells by human chorionic gonadotrophin and prostaglandin F2alpha. | Väänänen, JE., et al. 1998. Endocrine. 8: 261-7. PMID: 9741831
- Structural and molecular studies of human chorionic gonadotropin and its receptor. | Lustbader, JW., et al. 1998. Recent Prog Horm Res. 53: 395-424; discussion 424-5. PMID: 9769716
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Choriogonadotropin Antibody (2092) | sc-57054 | 500 µl supernatant | $322.00 |