Date published: 2025-12-18

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Cholesteryl butyrate (CAS 521-13-1)

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Alternate Names:
Cholesteryl butanoate
Application:
Cholesteryl butyrate is a cholesterol when combined with nanoparticles increases drug delivery
CAS Number:
521-13-1
Molecular Weight:
456.74
Molecular Formula:
C31H52O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cholesteryl butyrate is a compound that has garnered interest in materials science and biochemistry due to its unique structural properties. It consists of a cholesterol moiety esterified with butyric acid, which provides insights into lipid-lipid and lipid-protein interactions. Researchers employ cholesteryl butyrate in the study of cell membrane dynamics, where its incorporation can affect the fluidity and phase behavior of lipid bilayers. The compound is also relevant in the field of nanotechnology, specifically in the development of lipid-based nanoparticles for potential delivery systems. Investigations often focus on how its structural components influence the self-assembly and stability of these nanostructures. Additionally, cholesteryl butyrate is used in the exploration of liquid crystal formation and the thermotropic properties of cholesteric phases in various applications, contributing to the understanding of the physical chemistry of sterol derivatives.


Cholesteryl butyrate (CAS 521-13-1) References

  1. Cholesteryl butyrate in solid lipid nanospheres as an alternative approach for butyric acid delivery.  |  Pellizzaro, C., et al. 1999. Anticancer Res. 19: 3921-5. PMID: 10628332
  2. The effect of formulation and concentration of cholesteryl butyrate solid lipid nanospheres (SLN) on NIH-H460 cell proliferation.  |  Ugazio, E., et al. 2001. Eur J Pharm Biopharm. 52: 197-202. PMID: 11522486
  3. In vitro effects of cholesteryl butyrate solid lipid nanospheres as a butyric acid pro-drug on melanoma cells: evaluation of antiproliferative activity and apoptosis induction.  |  Salomone, B., et al. 2000. Clin Exp Metastasis. 18: 663-73. PMID: 11827070
  4. Cholesteryl butyrate solid lipid nanoparticles as a butyric acid pro-drug: effects on cell proliferation, cell-cycle distribution and c-myc expression in human leukemic cells.  |  Serpe, L., et al. 2004. Anticancer Drugs. 15: 525-36. PMID: 15166628
  5. Cholesteryl butyrate solid lipid nanoparticles inhibit adhesion of human neutrophils to endothelial cells.  |  Dianzani, C., et al. 2006. Br J Pharmacol. 148: 648-56. PMID: 16702992
  6. Solid lipid nanoparticles: could they help to improve the efficacy of pharmacologic treatments for brain tumors?  |  Brioschi, A., et al. 2007. Neurol Res. 29: 324-30. PMID: 17509234
  7. Application of comprehensive two-dimensional gas chromatography to sterols analysis.  |  Mitrevski, BS., et al. 2008. J Chromatogr A. 1214: 134-42. PMID: 18980770
  8. Cholesteryl butyrate solid lipid nanoparticles inhibit the adhesion and migration of colon cancer cells.  |  Minelli, R., et al. 2012. Br J Pharmacol. 166: 587-601. PMID: 22049973
  9. Solid lipid nanoparticles of cholesteryl butyrate inhibit the proliferation of cancer cells in vitro and in vivo models.  |  Minelli, R., et al. 2013. Br J Pharmacol. 170: 233-44. PMID: 23713413
  10. Modulation of butyrate anticancer activity by solid lipid nanoparticle delivery: an in vitro investigation on human breast cancer and leukemia cell lines.  |  Foglietta, F., et al. 2014. J Pharm Pharm Sci. 17: 231-47. PMID: 24934552
  11. Improved In Vitro Antileukemic Activity of All-Trans Retinoic Acid Loaded in Cholesteryl Butyrate Solid Lipid Nanoparticles.  |  Silva, EL., et al. 2016. J Nanosci Nanotechnol. 16: 1291-300. PMID: 27433579
  12. Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model.  |  Dianzani, C., et al. 2017. World J Gastroenterol. 23: 4200-4210. PMID: 28694660
  13. Optimization and comparison of CD4-targeting lipid-polymer hybrid nanoparticles using different binding ligands.  |  Cao, S., et al. 2018. J Biomed Mater Res A. 106: 1177-1188. PMID: 29271128

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cholesteryl butyrate, 1 g

sc-294015
1 g
$76.00

Cholesteryl butyrate, 5 g

sc-294015A
5 g
$352.00

Cholesteryl butyrate, 50 g

sc-294015B
50 g
$3473.00

Cholesteryl butyrate, 100 g

sc-294015C
100 g
$6941.00

Cholesteryl butyrate, 250 g

sc-294015D
250 g
$13775.00

Cholesteryl butyrate, 500 g

sc-294015E
500 g
$26525.00

Cholesteryl butyrate, 1 kg

sc-294015F
1 kg
$40295.00