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CHM-1 is a potent, selective antitumor agent in human hepatocellular carcinoma in vitro. CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization in vitro. Noted to cause cell cycle arrest at G2/M phase by activation of Cdc kinase activity. Also, CHM-1 exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells. Furthermore reported to induce translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CHM-1, 5 mg | sc-214686 | 5 mg | $143.00 | |||
CHM-1, 25 mg | sc-214686A | 25 mg | $797.00 |