Date published: 2025-10-15

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CHM-1 (CAS 154554-41-3)

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Alternate Names:
2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158
Application:
CHM-1 is a potent apoptosis inducer
CAS Number:
154554-41-3
Purity:
≥97%
Molecular Weight:
283.25 (anhydrous)
Molecular Formula:
C16H10FNO3 (anhydrous)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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CHM-1 is a potent, selective antitumor agent in human hepatocellular carcinoma in vitro. CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization in vitro. Noted to cause cell cycle arrest at G2/M phase by activation of Cdc kinase activity. Also, CHM-1 exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells. Furthermore reported to induce translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus.


CHM-1 (CAS 154554-41-3) References

Wang, S.W., et al., , CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol. Cancer Ther. 2nd ed., 7, 350-360, (2008)

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

CHM-1, 5 mg

sc-214686
5 mg
$143.00

CHM-1, 25 mg

sc-214686A
25 mg
$797.00