Date published: 2026-1-8

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Chlorhexidine-d8 Dihydrochloride (CAS 3697-42-5 (unlabeled))

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Alternate Names:
N,N′′-Bis(4-chlorophenyl-d8)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide Dihydrochloride; Lisium
Application:
Chlorhexidine-d8 Dihydrochloride is a bisbiguanide with bacteriostatic activity
CAS Number:
3697-42-5 (unlabeled)
Molecular Weight:
586.42
Molecular Formula:
C22H24D8Cl4N10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Chlorhexidine-d8 dihydrochloride, a deuterium-labeled form of chlorhexidine, serves as a valuable tool in various research applications, particularly in elucidating the mechanism of action and pharmacokinetics of chlorhexidine, a potent antiseptic and disinfectant. Deuterium labeling involves replacing hydrogen atoms with deuterium, a stable isotope, facilitating precise tracking and quantification of the compound′s distribution, metabolism, and elimination in biological systems. Researchers utilize Chlorhexidine-d8 dihydrochloride to investigate the interaction of chlorhexidine with biological membranes, proteins, and bacterial cell walls, providing insights into its antimicrobial activity and mode of action. Furthermore, Chlorhexidine-d8 dihydrochloride serves as a reference standard for developing analytical methods to quantify chlorhexidine levels in tissues, fluids, and environmental samples, enhancing the accuracy and reliability of pharmacokinetic and environmental fate studies. Its application extends to studying chlorhexidine′s efficacy in various formulations and delivery systems, optimizing its use in healthcare, personal care, and environmental disinfection. By leveraging Chlorhexidine-d8 dihydrochloride, researchers contribute to advancing our understanding of chlorhexidine′s antimicrobial properties, paving the way for the development of novel antimicrobial agents and improved disinfection strategies in research and industrial settings.


Chlorhexidine-d8 Dihydrochloride (CAS 3697-42-5 (unlabeled)) References

  1. 1:6-Di-4'-chlorophenyldiguanidohexane (hibitane); laboratory investigation of a new antibacterial agent of high potency.  |  DAVIES, GE., et al. 1954. Br J Pharmacol Chemother. 9: 192-6. PMID: 13172429
  2. Analysis of chlorhexidine gluconate in skin using tape stripping and ultrahigh-performance liquid chromatography-tandem mass spectrometry.  |  Zhao, X., et al. 2020. J Pharm Biomed Anal. 183: 113111. PMID: 32062012
  3. Chlorhexidine residues in sludge from municipal wastewater treatment plants: analytical determination and toxicity evaluation.  |  Golpe, MC., et al. 2022. Anal Bioanal Chem. 414: 6571-6580. PMID: 35829768
  4. Some toxicological observations on chlorhexidine.  |  Foulkes, DM. 1973. J Periodontal Res Suppl. 12: 55-60. PMID: 4269600

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Chlorhexidine-d8 Dihydrochloride, 1 mg

sc-217879
1 mg
$360.00

Chlorhexidine-d8 Dihydrochloride, 10 mg

sc-217879A
10 mg
$2290.00