CGS 21680C Sodium Salt (CAS 120225-64-1)

CGS 21680C Sodium Salt, a potent adenosine A2A receptor agonist, plays a pivotal role in neuroscience and pharmacological research. By selectively binding to and activating the adenosine A2A receptor subtype, CGS 21680C Sodium Salt modulates various cellular signaling pathways, particularly those involved in neurotransmission, neuroinflammation, and synaptic plasticity. Its mechanism of action involves the stimulation of adenylyl cyclase activity, leading to an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. This elevation in cAMP triggers downstream signaling cascades, ultimately influencing neuronal excitability, neurotransmitter release, and synaptic transmission. In research, CGS 21680C Sodium Salt has been extensively utilized to investigate the physiological and pathophysiological roles of adenosine A2A receptors in the central nervous system, including their involvement in neurodegenerative disorders, such as Parkinson′s disease and Alzheimer′s disease. Furthermore, CGS 21680C Sodium Salt has been instrumental in elucidating the potential of adenosine A2A receptor modulation for the treatment of various neurological conditions, including mood disorders, addiction, and cognitive dysfunction. Its precise pharmacological profile and selective receptor activity make it a valuable tool for advancing our understanding of adenosine receptor biology and developing novel strategies targeting the central nervous system.