Molecular structure of CGS 12066B dimaleate, CAS Number: 109028-10-6
CGS 12066B dimaleate (CAS 109028-10-6)
Application:
CGS 12066B dimaleate is a selective SR-1B agonist
CAS Number:
109028-10-6
Purity:
≥98%
Molecular Weight:
566.5
Molecular Formula:
C25H25F3N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CGS 12066B dimaleate is known to interact with certain receptors in the central nervous system, affecting neurotransmitter release and neuronal activity. CGS 12066B dimaleate modulates the release of dopamine and other neurotransmitters, making it useful for studying the mechanisms of neurotransmission. CGS 12066B dimaleate has an affinity for specific receptor subtypes, and its effects on neuronal signaling pathways have been studied. Its ability to selectively target certain receptors has made it useful for understanding the complex interactions within the nervous system. CGS 12066B dimaleate has contributed to our understanding of neurotransmission.
CGS 12066B dimaleate (CAS 109028-10-6) References
- Effects of the selective 5-HT1B agonist, CGS 12066B, on sleep/waking stages and EEG power spectrum in rats. | Bjorvatn, B. and Ursin, R. 1994. J Sleep Res. 3: 97-105. PMID: 10607113
- Effect of 5-HT(1B) receptor ligands on self-administration of ethanol in an operant procedure in rats. | Tomkins, DM. and O'Neill, MF. 2000. Pharmacol Biochem Behav. 66: 129-36. PMID: 10837852
- Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plus-maze: profile comparisons with 8-OH-DPAT, CGS 12066B, TFMPP and mCPP. | Rodgers, RJ., et al. 1992. Behav Pharmacol. 3: 621-634. PMID: 11224163
- Hypothermia and the 5-HT syndrome induced by CGS 12066B independently of 5-HT(1B) receptor activation. | Bjorvatn, B., et al. 1996. Behav Pharmacol. 7: 462-469. PMID: 11224442
- Effects of the 5-HT1 receptor agonists DP-5-CT, CGS 12066B, and RU 24969 on plasma adrenaline and glucose levels in the rat. | Laude, D., et al. 1990. Naunyn Schmiedebergs Arch Pharmacol. 342: 378-81. PMID: 2255331
- Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? | Schoeffter, P. and Hoyer, D. 1989. Naunyn Schmiedebergs Arch Pharmacol. 339: 675-83. PMID: 2770889
- Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. | Neale, RF., et al. 1987. Eur J Pharmacol. 136: 1-9. PMID: 3496228
- 5-HT1B/1D agonist CGS-12066B attenuates clasp knife reflex in the cat. | Miller, JF., et al. 1995. J Neurophysiol. 74: 453-6. PMID: 7472346
- Differential effects of CGS 12066B and CP-94,253 on murine social and agonistic behaviour. | Bell, R., et al. 1995. Pharmacol Biochem Behav. 52: 7-16. PMID: 7501681
- Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice. | Alhaider, AA. and Wilcox, GL. 1993. J Pharmacol Exp Ther. 265: 378-85. PMID: 7682614
- Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo. | Prisco, S., et al. 1994. J Pharmacol Exp Ther. 271: 83-90. PMID: 7965760
- Hippocampal serotonin 5-HT1A receptor enhances acetylcholine release in conscious rats. | Izumi, J., et al. 1994. J Neurochem. 62: 1804-8. PMID: 8158130
Activator of:
SR-1A, and SR-1B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CGS 12066B dimaleate, 10 mg | sc-201106 | 10 mg | $87.00 | |||
| US: Only available in the US | ||||||
CGS 12066B dimaleate, 50 mg | sc-201106A | 50 mg | $356.00 | |||
| US: Only available in the US | ||||||