Molecular structure of CGP 52432, CAS Number: 139667-74-6
CGP 52432 (CAS 139667-74-6)
Alternate Names:
3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid
Application:
CGP 52432 is A selective and effective GABAB receptor antagonist
CAS Number:
139667-74-6
Molecular Weight:
384.24
Molecular Formula:
C15H24Cl2NO4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CGP 52432 is a selective and effective GABAB receptor antagonist.
CGP 52432 (CAS 139667-74-6) References
- The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep. | Jackson, GL. and Kuehl, D. 2002. Exp Biol Med (Maywood). 227: 315-20. PMID: 11976401
- GABA(B) receptors accentuate neural excitation contrast in rat insular cortex. | Fujita, S., et al. 2011. Neuroscience. 199: 259-71. PMID: 21958865
- Kinetics of GABAB autoreceptor-mediated suppression of GABA release in rat insular cortex. | Kobayashi, M., et al. 2012. J Neurophysiol. 107: 1431-42. PMID: 22190629
- Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: relevance to antidepressant action. | Felice, D., et al. 2012. Neuropharmacology. 63: 1380-8. PMID: 22884610
- Spinal cord GABA receptors modulate the exercise pressor reflex in decerebrate rats. | Wang, HJ., et al. 2013. Am J Physiol Regul Integr Comp Physiol. 305: R42-9. PMID: 23637133
- CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. | Lanza, M., et al. 1993. Eur J Pharmacol. 237: 191-5. PMID: 8103461
- Electrophysiological actions of GABAB agonists and antagonists in rat dorso-lateral septal neurones in vitro. | Bon, C. and Galvan, M. 1996. Br J Pharmacol. 118: 961-7. PMID: 8799569
- Blockade of GABA(B) receptors facilitates muscarinic agonist-induced epileptiform activity in immature rat piriform cortex in vitro. | Libri, V., et al. 1998. Naunyn Schmiedebergs Arch Pharmacol. 358: 168-74. PMID: 9750001
- GABA(B) receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord. | Bonanno, G., et al. 1998. Eur J Pharmacol. 362: 143-8. PMID: 9874164
Inhibitor of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CGP 52432, 10 mg | sc-361141 | 10 mg | $209.00 | |||
CGP 52432, 50 mg | sc-361141A | 50 mg | $882.00 |