Molecular structure of Cerulenin (source Cephalosporium caerulens), CAS Number: 17397-89-6
Cerulenin (source Cephalosporium caerulens) (CAS 17397-89-6)
Alternate Names:
Helicocerin; (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide
Application:
Cerulenin (source Cephalosporium caerulens) is An inhibitor fatty acid and sterol biosynthesis
CAS Number:
17397-89-6
Purity:
≥98%
Molecular Weight:
223.27
Molecular Formula:
C12H17NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Cerulenin (source Cephalosporium caerulens) has broad application in lipid biochemistry as an inhibitor of fatty acid and sterol biosynthesis. Cerulenin (source Cephalosporium caerulens) binds to beta-keto-acyl-ACP synthase, blocking the interaction of malonyl CoA. It also inhibits bacterial fatty acid synthesis, acting on the FabH, FabB and FabF condensation enzymes. Furthermore, Cerulenin (source Cephalosporium caerulens) stimulates fatty acid oxidation and inhibits HMG-CoA synthetase activity.
Cerulenin (source Cephalosporium caerulens) (CAS 17397-89-6) References
- Cerulenin-mediated apoptosis is involved in adenine metabolic pathway. | Chung, KS., et al. 2006. Biochem Biophys Res Commun. 349: 1025-31. PMID: 16962997
- Identification of a cerulenin resistance gene from Monascus pilosus. | Zhang, M. and Miyake, T. 2007. DNA Seq. 18: 68-72. PMID: 17364816
- Cerulenin inhibits de novo sophorolipid synthesis of Candida bombicola. | Van Bogaert, IN., et al. 2008. Biotechnol Lett. 30: 1829-32. PMID: 18568403
- Cerulenin analogues as inhibitors of efflux pumps in drug-resistant Candida albicans. | Diwischek, F., et al. 2009. Arch Pharm (Weinheim). 342: 150-64. PMID: 19253321
- Transepithelial transport of Cerulenin across Caco-2 cell monolayers. | Fu, DH., et al. 2009. Eur J Drug Metab Pharmacokinet. 34: 67-72. PMID: 19645214
- Enhanced antitumor activity of epirubicin combined with cerulenin in osteosarcoma. | Liu, ZL., et al. 2012. Mol Med Rep. 5: 326-30. PMID: 22052253
- Cerulenin-induced apoptosis is mediated by disrupting the interaction between AIF and hexokinase II. | Jeong, NY. and Yoo, YH. 2012. Int J Oncol. 40: 1949-56. PMID: 22426850
- Cerulenin upregulates heat shock protein-70 gene expression in chicken muscle. | Dridi, S., et al. 2013. Poult Sci. 92: 2745-53. PMID: 24046423
- Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice. | Cheng, G., et al. 2013. PLoS One. 8: e75980. PMID: 24086674
- Structural insights into bacterial resistance to cerulenin. | Trajtenberg, F., et al. 2014. FEBS J. 281: 2324-38. PMID: 24641521
- Cerulenin suppresses ErbB2-overexpressing breast cancer by targeting ErbB2/PKM2 pathway. | Lv, S., et al. 2022. Med Oncol. 40: 5. PMID: 36308575
- Cerulenin is a potent inhibitor of antigen processing by antigen-presenting cells. | Falo, LD., et al. 1987. J Immunol. 139: 3918-23. PMID: 3693897
- [Mechanism of action of cerulenin on fatty acid synthetase and cerulenin resistance in a cerulenin-producing fungus]. | Tomoda, H., et al. 1985. Seikagaku. 57: 190-201. PMID: 3894530
- Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene. | Inokoshi, J., et al. 1994. Mol Gen Genet. 244: 90-6. PMID: 8041367
- Cerulenin inhibits the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in brefeldin A-resistant cell lines. | Oda, T. and Wu, HC. 1993. J Biol Chem. 268: 12596-602. PMID: 8509400
Inhibitor of:
Fatty Acid Synthase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cerulenin (source Cephalosporium caerulens), 5 mg | sc-396822 | 5 mg | $149.00 | |||
Cerulenin (source Cephalosporium caerulens), 10 mg | sc-396822A | 10 mg | $313.00 | |||
Cerulenin (source Cephalosporium caerulens), 50 mg | sc-396822B | 50 mg | $1062.00 |