Ceramide C6 (CAS 124753-97-5)
See product citations (42)
QUICK LINKS
Ceramide C6 is a nonphysiologic analog displaying cell-permeability and biological activity. Actions of Ceramide C6 include stimulation of protein phosphatase 2A and activation of MAP kinase. Molt-4 leukemia cells are arrested at the G0/G1 phase (10μM) and apoptosis is induced by Ceramide C6 at concentrations greater than 15μM. Ceramide C6 has been observed to enhance expression of COX-2 in rat granulosa cells and stimulate growth of aortic smooth muscle cells in bovines. Further observations of the chemical functions of Ceramide C6 include apoptosis of HL-60, induction, suppression of insulin-induced Tyr phosphorylation, inhibition of neurite growth and inhibition of glycoprotein traffic via the secretory pathway. Ceramide C6 is also known as N-Hexanoyl-D-Sphingosine, N-hexanoyl-D-sphingosine, C6 Ceramide, and Caproyl ceramide.
Ceramide C6 (CAS 124753-97-5) References
- Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. | Voelkel-Johnson, C., et al. 2005. Mol Cancer Ther. 4: 1320-7. PMID: 16170023
- Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition. | Ji, C., et al. 2010. Oncogene. 29: 6557-68. PMID: 20802518
- Nanoliposomal ceramide prevents in vivo growth of hepatocellular carcinoma. | Tagaram, HR., et al. 2011. Gut. 60: 695-701. PMID: 21193455
- Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models. | Adiseshaiah, PP., et al. 2013. Cancer Lett. 337: 254-65. PMID: 23664889
- The combined effect of encapsulating curcumin and C6 ceramide in liposomal nanoparticles against osteosarcoma. | Dhule, SS., et al. 2014. Mol Pharm. 11: 417-27. PMID: 24380633
- Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells. | Raines, MA., et al. 1993. J Biol Chem. 268: 14572-5. PMID: 7686898
- Role for ceramide in cell cycle arrest. | Jayadev, S., et al. 1995. J Biol Chem. 270: 2047-52. PMID: 7836432
- Inhibition of glycoprotein traffic through the secretory pathway by ceramide. | Rosenwald, AG. and Pagano, RE. 1993. J Biol Chem. 268: 4577-9. PMID: 8383117
- Ceramide activates heterotrimeric protein phosphatase 2A. | Dobrowsky, RT., et al. 1993. J Biol Chem. 268: 15523-30. PMID: 8393446
- Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. | Jarvis, WD., et al. 1996. J Biol Chem. 271: 8275-84. PMID: 8626522
- Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1. | Kanety, H., et al. 1996. J Biol Chem. 271: 9895-7. PMID: 8626623
- Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis. | Santana, P., et al. 1996. Endocrinology. 137: 2480-9. PMID: 8641202
- Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons. | de Chaves, EI., et al. 1997. J Biol Chem. 272: 3028-35. PMID: 9006952
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ceramide C6, 5 mg | sc-3527 | 5 mg | $88.00 | |||
Ceramide C6, 25 mg | sc-3527A | 25 mg | $330.00 |