cementum attachment protein Antibody (3G9): sc-53947

Cementum attachment protein Antibody (3G9) is a mouse monoclonal IgG1 kappa light chain antibody that detects cementum attachment protein in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-cementum attachment protein antibody (3G9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cementum attachment protein, also known as CAP, is a collagenous protein predominantly found in the matrix of tooth cementum, where CAP plays a crucial role in dental health by binding with high affinity to non-demineralized root surfaces, hydroxyapatite, and fibronectin. This binding is essential for promoting mesenchymal cell attachment, which is vital for cementogenesis—the process of forming cementum, a calcified tissue covering tooth roots. Cementum attachment protein is implicated in periodontal homeostasis and wound healing, as CAP can recruit putative cementoblastic populations on root slices in vitro. Notably, integrin α5β1 mediates periodontal-derived cell attachment, such as human gingival fibroblasts and human periodontal ligament fibroblasts, to cementum attachment protein, highlighting CAP′s importance in periodontal tissue integrity and repair.

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cementum attachment protein Antibody (3G9) References:

1. Cementum attachment protein enriches putative cementoblastic populations on root surfaces in vitro.  |  BarKana, I., et al. 2000. J Dent Res. 79: 1482-8. PMID: 11005732
2. Expression of cementum-derived attachment protein in bovine tooth germ during cementogenesis.  |  Saito, M., et al. 2001. Bone. 29: 242-8. PMID: 11557368
3. Bone morphogenetic protein 2 induces the expression of cementum attachment protein in human periodontal ligament clones.  |  Pitaru, S., et al. 2002. Connect Tissue Res. 43: 257-64. PMID: 12489168
4. Binding of a cementum attachment protein to extracellular matrix components and to dental surfaces.  |  Pitaru, S., et al. 1992. J Periodontal Res. 27: 640-6. PMID: 1334146
5. Specific cementum attachment protein enhances selectively the attachment and migration of periodontal cells to root surfaces.  |  Pitaru, S., et al. 1995. J Periodontal Res. 30: 360-8. PMID: 7494179
6. Molecular and cellular interactions of a cementum attachment protein with periodontal cells and cementum matrix components.  |  Pitaru, S., et al. 1993. J Periodontal Res. 28: 560-2. PMID: 8263731
7. Characterization of a collagenous cementum-derived attachment protein.  |  Wu, D., et al. 1996. J Bone Miner Res. 11: 686-92. PMID: 9157784
8. Cementum attachment protein manifestation is restricted to the mineralized tissue forming cells of the periodontium.  |  Bar-Kana, I., et al. 1998. Eur J Oral Sci. 106 Suppl 1: 357-64. PMID: 9541248
9. Differential chemotactic effect of cementum attachment protein on periodontal cells.  |  Metzger, Z., et al. 1998. J Periodontal Res. 33: 126-9. PMID: 9553872

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cementum attachment protein Antibody (3G9) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-cementum attachment protein Antibody (3G9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cementum attachment protein Antibody (3G9) Specifications

Alternate Product Name: cementum attachment protein

Product Clone Name: 3G9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: cementum attachment protein

Epitope Species: bovine

Product Reactivity/Detection: cementum attachment protein

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for cementum attachment protein Antibody (3G9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin