CD4 Antibody (RPA-T4): sc-53664

CD4 Antibody (RPA-T4) is a mouse monoclonal IgG1 antibody designed to detect the human CD4 protein, also known as T4 or Leu-3. Anti-CD4 antibody (RPA-T4) targets CD4, a membrane-bound glycoprotein composed of four extracellular immunoglobulin-like domains, which undergoes essential post-translational modifications such as glycosylation. These modifications are crucial for CD4′s stability, proper folding, and interactions with other proteins, including the T cell receptor (TCR) and class II major histocompatibility complex (MHC) molecules. CD4 plays a pivotal role in the immune system by enhancing the binding affinity between the TCR and antigen-MHC complexes, thereby facilitating effective T cell activation and robust adaptive immune responses. Additionally, CD4 serves as the primary receptor for HIV, making CD4 a key target for research on viral entry and immune system interactions. CD4 monoclonal antibody (RPA-T4) is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM), providing versatile applications for analyzing CD4 expression and function in various experimental settings. Anti-CD4 antibody (RPA-T4) is reactive with human CD4, allowing researchers to investigate CD4 expression on T helper cells, macrophages, dendritic cells, and other immune cell types. CD4 antibody (RPA-T4) enables scientists to explore the impact of post-translational modifications on CD4′s role in immune regulation, T cell development, and disease processes, thereby advancing our understanding of immune system dynamics and contributing to the development of targeted therapies and diagnostic tools.

The preferred CD4 antibody is CD4 Antibody (GK1.5): sc-13573.