CD24 Antibody (ALB9): sc-58999

CD24 Antibody (ALB9) is a mouse monoclonal IgG1 antibody that detects CD24 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). CD24 is a glycosylphosphatidylinositol (GPI)-anchored membrane sialoglycoprotein predominantly expressed on pro-B, pre-B, and mature B cells, with expression diminishing following B cell activation. CD24 is also present on granulocytes and a small subset of thymocytes, as well as in neuroblastomas, but is absent in plasma cells. Anti-CD24 antibody (ALB9) helps researchers study CD24′s crucial role in regulating B cell proliferation and differentiation, serving as a marker for B cell maturation and being implicated in various hematological malignancies and solid tumors. CD24′s localization within the cell is significant; CD24 typically resides in the apical region of the cell membrane, and a shift to cytoplasmic staining has been identified as a surrogate marker for stromal invasion in ovarian serous tumors of borderline malignancy. CD24′s ability to act as a differentiation marker for mature resting B cells, which disappears upon stimulation, further underscores CD24′s importance in understanding B cell biology and cancer progression. CD24 monoclonal antibody (ALB9) is an essential tool for researchers investigating these critical pathways.

The preferred CD24 antibody is CD24 Antibody (SN3): sc-19585.