CAY10408 (CAS 212310-16-2)
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Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does not bind appreciably to any of the other murine EP receptors or TP, DP, IP, or FP receptors (1). This chemical is a free acid, 2-series analog of butaprost. It is the less active C-16 epimer compared to the 16(S) isomer, which has the same stereochemistry as butaprost. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various animal and human cells and tissues (2). Since the majority of reports related to butaprost utilize the methyl ester derivative, (3,4) it may be some time before the precise pharmacology of the free acid compounds, like this chemical, is reported.
CAY10408 (CAS 212310-16-2) References
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- Responses of sea urchins (Strongylocentrotus intermedius) with different sexes to CO2-induced seawater acidification: Histology, physiology, and metabolomics. | Cui, D., et al. 2022. Mar Pollut Bull. 178: 113606. PMID: 35378459
- Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils. | Talpain, E., et al. 1995. Br J Pharmacol. 114: 1459-65. PMID: 7606349
- Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. | Regan, JW., et al. 1994. Mol Pharmacol. 46: 213-20. PMID: 8078484
- Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. | Kiriyama, M., et al. 1997. Br J Pharmacol. 122: 217-24. PMID: 9313928
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAY10408, 1 mg | sc-223759 | 1 mg | $133.00 | |||
CAY10408, 5 mg | sc-223759A | 5 mg | $600.00 |