Cathepsin L Inhibitor I (CAS 108005-94-3)
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Cathepsin L Inhibitor I is a compound of interest within the biochemical research community for its role in inhibiting the protease activity of Cathepsin L, an enzyme implicated in various cellular processes including protein degradation. This inhibitor is particularly useful for scientists studying the enzyme′s function and regulation, as well as its involvement in pathological states. By blocking Cathepsin L activity, researchers can dissect the enzyme′s contribution to the breakdown of proteins within cells, which has implications for understanding diseases where protein degradation is dysregulated. The inhibitor′s selectivity is also under scrutiny, as it offers insights into designing more efficient inhibitors that can modulate the enzyme with minimal off-target effects. Investigations involving Cathepsin L Inhibitor I extend to areas such as cell biology, where understanding the intracellular pathways affected by protease activity is crucial.
Cathepsin L Inhibitor I (CAS 108005-94-3) References
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- Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L. | Boland, B. and Campbell, V. 2004. Neurobiol Aging. 25: 83-91. PMID: 14675734
- Proinsulin/insulin is synthesized locally and prevents caspase- and cathepsin-mediated cell death in the embryonic mouse retina. | Valenciano, AI., et al. 2006. J Neurochem. 99: 524-36. PMID: 17029604
- Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression. | Hamano, T., et al. 2008. Eur J Neurosci. 27: 1119-30. PMID: 18294209
- PEGylation modulates the interfacial kinetics of proteases on peptide-capped gold nanoparticles. | Free, P., et al. 2009. Chem Commun (Camb). 5009-11. PMID: 19668832
- Cathepsin L digestion of nanobioconjugates upon endocytosis. | Sée, V., et al. 2009. ACS Nano. 3: 2461-8. PMID: 19728690
- Gold nanoparticles delivery in mammalian live cells: a critical review. | Lévy, R., et al. 2010. Nano Rev. 1: PMID: 22110850
- Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria. | Lee, HM., et al. 2013. Glia. 61: 441-52. PMID: 23280493
- Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. | Wang, YR., et al. 2013. PLoS One. 8: e75702. PMID: 24073275
- Long-term incubation with proteasome inhibitors (PIs) induces IκBα degradation via the lysosomal pathway in an IκB kinase (IKK)-dependent and IKK-independent manner. | Lee, KH., et al. 2013. J Biol Chem. 288: 32777-32786. PMID: 24085292
- Azadirachtin-induced apoptosis involves lysosomal membrane permeabilization and cathepsin L release in Spodoptera frugiperda Sf9 cells. | Wang, Z., et al. 2015. Int J Biochem Cell Biol. 64: 126-35. PMID: 25849458
- Inflammasome priming increases retinal pigment epithelial cell susceptibility to lipofuscin phototoxicity by changing the cell death mechanism from apoptosis to pyroptosis. | Brandstetter, C., et al. 2016. J Photochem Photobiol B. 161: 177-83. PMID: 27240191
- Angiotensin II-Induced vascular remodeling and hypertension involves cathepsin L/V- MEK/ERK mediated mechanism. | Lu, Y., et al. 2020. Int J Cardiol. 298: 98-106. PMID: 31668507
- Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling. | Jiang, M., et al. 2020. J Neurochem. 155: 300-312. PMID: 32330298
- A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells. | Park, SH., et al. 2022. Chem Commun (Camb). 58: 4079-4082. PMID: 35266486
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cathepsin L Inhibitor I, 1 mg | sc-364671 | 1 mg | $269.00 |