Molecular structure of Cathepsin G Inhibitor I, CAS Number: 429676-93-7
Cathepsin G Inhibitor I (CAS 429676-93-7)
See product citations (3)
Application:
Cathepsin G Inhibitor I is a cathepsin G inhibitor
CAS Number:
429676-93-7
Purity:
≥98%
Molecular Weight:
620.64
Molecular Formula:
C36H33N2O6P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G. Cathepsin G Inhibitor I weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase.
Cathepsin G Inhibitor I (CAS 429676-93-7) References
- Cathepsin G, a leukocyte protease, activates coagulation factor VIII. | Gale, AJ. and Rozenshteyn, D. 2008. Thromb Haemost. 99: 44-51. PMID: 18217133
- The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase. | Mambole, A., et al. 2008. J Biol Chem. 283: 23627-35. PMID: 18586676
- Cathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1. | Son, ED., et al. 2009. J Dermatol Sci. 53: 150-2. PMID: 18835135
- Development of an SPR imaging biosensor for determination of cathepsin G in saliva and white blood cells. | Gorodkiewicz, E., et al. 2011. Mikrochim Acta. 173: 407-413. PMID: 21660086
- Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages. | Danelishvili, L., et al. 2011. Front Microbiol. 2: 281. PMID: 22275911
- Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. | Saadoun, S., et al. 2012. Ann Neurol. 71: 323-33. PMID: 22374891
- Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils. | Faraday, N., et al. 2013. PLoS One. 8: e71447. PMID: 23940756
- Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin. | Woo, SM., et al. 2017. Oncotarget. 8: 106672-106684. PMID: 29290980
- Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry. | Guerra, M., et al. 2019. ACS Cent Sci. 5: 539-548. PMID: 30937381
- Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation. | Burgener, SS., et al. 2019. Cell Rep. 27: 3646-3656.e5. PMID: 31216481
- The Inhibition of Cathepsin G on Endometrial Explants With Endometrosis in the Mare. | Amaral, A., et al. 2020. Front Vet Sci. 7: 582211. PMID: 33195599
- Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation. | Cheung, P., et al. 2021. Nat Immunol. 22: 711-722. PMID: 34017121
- Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples. | Frey, DL., et al. 2021. J Vis Exp.. PMID: 34096915
Inhibitor of:
cathepsin G.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cathepsin G Inhibitor I, 1 mg | sc-221399 | 1 mg | $286.00 |