Molecular structure of CASIN, CAS Number: 425399-05-9
CASIN (CAS 425399-05-9)
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Alternate Names:
2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
Application:
CASIN is a Cdc42 GTPase inhibitor
CAS Number:
425399-05-9
Purity:
≥98%
Molecular Weight:
306.40
Molecular Formula:
C20H22N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CASIN is a Cdc42 GTPase inhibitor (IC50 = 2 muM). It reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs and reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs. CASIN also increases histone H4K16 acetylation in aged HSCs.
CASIN (CAS 425399-05-9) References
- The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation. | Palazzo, A., et al. 2016. J Thromb Haemost. 14: 2524-2535. PMID: 27685868
- Aged murine hematopoietic stem cells drive aging-associated immune remodeling. | Leins, H., et al. 2018. Blood. 132: 565-576. PMID: 29891535
- Cadmium Activates Noncanonical Wnt Signaling to Impair Hematopoietic Stem Cell Function in Mice. | Zhao, Y., et al. 2018. Toxicol Sci. 165: 254-266. PMID: 29939372
- Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. | Liu, W., et al. 2019. Leukemia. 33: 749-761. PMID: 30254339
- Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. | Yang, JQ., et al. 2019. Clin Exp Allergy. 49: 92-107. PMID: 30307073
- Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. | Nguyen, P., et al. 2019. Front Oncol. 9: 958. PMID: 31632904
- CASIN and AMD3100 enhance endothelial cell proliferation, tube formation and sprouting. | Kalkan, BM., et al. 2020. Microvasc Res. 130: 104001. PMID: 32198058
- Cdc42 regulates cell polarization and contractile actomyosin rings during terminal differentiation of human erythroblasts. | Ubukawa, K., et al. 2020. Sci Rep. 10: 11806. PMID: 32678227
- Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. | Florian, MC., et al. 2020. Aging Cell. 19: e13208. PMID: 32755011
- Soy Isoflavones Accelerate Glial Cell Migration via GPER-Mediated Signal Transduction Pathway. | Ariyani, W., et al. 2020. Front Endocrinol (Lausanne). 11: 554941. PMID: 33250856
- Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity. | Amoah, A., et al. 2022. Haematologica. 107: 393-402. PMID: 33440922
- Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. | Duan, X., et al. 2021. Sci Rep. 11: 13170. PMID: 34162972
- miR-185-5p Regulates Inflammation and Phagocytosis through CDC42/JNK Pathway in Macrophages. | Ma, X., et al. 2022. Genes (Basel). 13: PMID: 35328023
- Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. | Kalim, KW., et al. 2022. J Immunother Cancer. 10: PMID: 36427906
- Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice. | Montserrat-Vazquez, S., et al. 2022. NPJ Regen Med. 7: 78. PMID: 36581635
Inhibitor of:
4931406P16Rik, A430078G23Rik, A730069N07Rik, ARHGAP21, ARHGAP23, ARHGAP4, ARHGEF17, ARHGEF19, ARHGEF37, ARHGEF38, ARHGEF39, ARHGEF5_Arhgef5, ARHGEF9, ARL4D, ARNO, Atlastin, Cdc42, Cdc42EP2, Cdc42EP3, Cdc42EP4, Cdc42EP5, CdGAP, Centaurin γ3, CIP4, DBC-2, DOCK 6, EPI64, FGD6, Gm1527, Lbc, Ly-GDI, MCF2L2, MRCKγ, oligophrenin-1, OTTMUSG00000005723, PLEKHG1, PLEKHG2, PLEKHG3, PLEKHG5, Rab 27b, Rab 38, Rab 43, Rab 7L1, RAB3IL1, Rac 1, Rac 3, Rac GAP1, racrac2, RAPGEF5, RASA4B, Rho GAP p190, Rho H, Rho T1, Rho V, RHOBTB1, Rhotekin, Rhotekin 2, RILPL1, Rnd1, Sar1, SLIT-ROBO Rho GTPase activating protein (SRGAP), TBC1D13, TBC1D30, TC10, TOCA-1, and WRCH1.Activator of:
A430078G23Rik, ARFGAP1, ARHGAP10, ARHGAP11A, ARHGAP11B, ARHGAP30, ARHGAP8, CAP1, Cdc42, DOCK 180, Drac1/2, Elmo1, PARD6B, PDZ-RhoGEF, and rac1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CASIN, 10 mg | sc-397016 | 10 mg | $460.00 |