casein kinase IIα/α' Antibody (31): sc-136281
- casein kinase IIα/α' Antibody (31) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 1-123 of casein kinase IIα of rat origin
- recommended for detection of casein kinase IIα and casein kinase IIα′ of mouse, rat and human origin by WB and IP
- See casein kinase IIα (E-7): sc-373894 for casein kinase IIα/α' antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for casein kinase IIα/α' Antibody (31). This work is in progress.
QUICK LINKS
SEE ALSO...
casein kinase IIα/α′ Antibody (31) is a mouse monoclonal IgG1 antibody designed to recognize both casein kinase IIα (CK2α, also known as CSNK2A1) and casein kinase IIα′ (CK2α′, or CSNK2A2) proteins. Anti-casein kinase IIα/α′ antibody (31) is raised against amino acids 1-123 of rat-derived CK2α, ensuring robust reactivity with the CK2α and CK2α′ isoforms from mouse, rat, and human species when used in western blotting (WB) and immunoprecipitation (IP) applications. Casein kinase II is a ubiquitous serine/threonine protein kinase that localizes primarily to the cytoplasm and nucleus, playing a critical role in regulating various cellular processes such as cell cycle progression, DNA replication and repair, apoptosis, and transcriptional regulation. The CK2α and CK2α′ subunits form part of the tetrameric CK2 complex, which is essential for its catalytic activity and regulation through interactions with regulatory β subunits. The presence and activity of CK2 are vital for maintaining cellular homeostasis, and dysregulation of CK2α/α′ has been implicated in numerous diseases, including cancer, making CK2α/α′ a significant target for biomedical research. By phosphorylating over a hundred different substrates, including key nuclear oncoproteins and transcription factors, CK2α/α′ influences critical signaling pathways and gene expression mechanisms. Anti-casein kinase IIα/α′ antibody (31) is an indispensable tool for researchers investigating the multifaceted roles of CK2α and CK2α′ in cellular biology and disease pathology, providing reliable detection and analysis of these important kinases in various experimental settings.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
casein kinase IIα/α' Antibody (31) | sc-136281 | 50 µg/0.5 ml | $322.00 |