casein kinase Iγ2 Antibody (26-P): sc-130365
- casein kinase Iγ2 Antibody (26-P) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant casein kinase Iγ2 of human origin
- recommended for detection of casein kinase Iγ2 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for casein kinase Iγ2 Antibody (26-P). This work is in progress.
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casein kinase Iγ2 Antibody (26-P) is a mouse monoclonal IgG2a antibody that detects casein kinase Iγ2 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Casein kinase Iγ2 is a vital member of the casein kinase I family, which plays a crucial role in various cellular processes, including the regulation of circadian rhythms, cell division, and apoptosis. Casein kinase Iγ2 is primarily located in the cytoplasm and nucleus, where casein kinase Iγ2 participates in signaling pathways that influence gene expression and cellular responses to stress. The localization of casein kinase Iγ2 is significant because this positioning allows for precise modulation of substrates, which include key proteins involved in cell cycle regulation and DNA repair mechanisms. By phosphorylating these substrates, casein kinase Iγ2 can alter their activity, stability, and interactions, thereby impacting critical cellular functions. The regulation of such processes by casein kinase Iγ2 underscores its importance in maintaining cellular homeostasis and potential implications in various diseases, including cancer and neurodegenerative disorders. With specificity for human samples and proven applications, anti-casein kinase Iγ2 antibody (26-P) serves as an essential tool for researchers investigating the intricate roles of this protein in health and disease.
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casein kinase Iγ2 Antibody (26-P) References:
- Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. | Mishra, SK., et al. 2004. Oncogene. 23: 4422-9. PMID: 15077195
- SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. | Shirogane, T., et al. 2005. J Biol Chem. 280: 26863-72. PMID: 15917222
- Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. | Guo, X., et al. 2008. Oncogene. 27: 7235-47. PMID: 18794808
- Bidirectional regulation of Aβ levels by Presenilin 1. | Bustos, V., et al. 2017. Proc Natl Acad Sci U S A. 114: 7142-7147. PMID: 28533411
- MicroRNA-155 regulates casein kinase 1 gamma 2: a potential pathogenetic role in chronic lymphocytic leukemia. | Zhang, T., et al. 2017. Blood Cancer J. 7: e606. PMID: 28885613
- The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms. | Fulcher, LJ., et al. 2018. Sci Signal. 11: PMID: 29789297
- Phosphorylation of IRS4 by CK1γ2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway. | Li, X., et al. 2018. Theranostics. 8: 3643-3653. PMID: 30026872
- Amyloidogenic and anti-amyloidogenic properties of presenilin 1. | Bustos, V., et al. 2021. Adv Pharmacol. 90: 239-251. PMID: 33706935
- CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells. | Nguyen Hoang, AT., et al. 2021. PLoS One. 16: e0246264. PMID: 33861751
- Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels. | Bustos, VH., et al. 2024. ACS Chem Biol. 19: 37-47. PMID: 38079390
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
casein kinase Iγ2 Antibody (26-P) | sc-130365 | 100 µg/ml | $339.00 |